Results 231 to 240 of about 835,285 (264)

Stability-Indicating Methods for the Determination of Rofecoxib

Journal of the Chinese Chemical Society, 2006
Two stability indicating methods have been developed for determining rofecoxib in the presence of its degradation product. The first suggested method is high performance liquid chromatography (HPLC), in which analysis is carried out using hypersil BDS C18 column (250 × 4.6 mm I.D.) with mobile Phase consisting of 0.05 M phosphate buffer (pH 3.5) and ...
M. M. El-Henawee, M. Ibraheim, Said Osman, M. M. Ayad   +3 more
openaire   +1 more source

A Stability-Indicating LC Method for Lumefantrine

Chromatographia, 2008
A simple, rapid, and precise method is developed for the quantitative determination of lumefantrine (Lume) in active pharmaceutical ingredient (API). A chromatographic separation of Lume and its degradants were achieved with an X-Terra RP18, 250 × 4.6 mm, and 5 μ analytical column using buffer–acetonitrile (30:70 v/v).
Kiran R. Patil, Vipul P. Rane, Jaiprakash N. Sangshetti, Devanand B. Shinde   +3 more
openaire   +1 more source

A Stability-Indicating LC Method for Rimonabant

Chromatographia, 2008
A simple, inexpensive and rapid isocratic LC method has been developed for the quantative determination of Rimonabant, an anti-obesity drug. The method can also be employed for the determination of Rimonabant and its impurities in the bulk drug. Degradation studies were performed on the bulk drug by heating to 60 °C, exposure to UV light at 254 nm ...
T. Satyanarayana Raju, M. Ravikumar, K. Vijay Kumar, K. S. V. Raghavachary, M. Satish Varma, Ch. Surya Naga Malleswara Rao, P. Yadagiri Swamy   +6 more
openaire   +1 more source

Stability-Indicating Spectrophotometric and Densitometric Methods for Determination of Aceclofenac

Drug Development and Industrial Pharmacy, 2002
Three methods were developed for the determination of aceclofenac in the presence of its degradation product, diclofenac. In the first method, third-derivative spectrophotometry (D3) is used. The D3 absorbance is measured at 283 nm where its hydrolytic degradation product diclofenac does not interfere.
Y S, el-Saharty, M, Refaat, S Z, el-Khateeb   +2 more
openaire   +2 more sources

Validated stability‐indicating TLC method for the determination of noscapine

Drug Testing and Analysis, 2009
AbstractA sensitive, selective, precise and stability‐indicating thin‐layer chromatographic (TLC) method was developed and validated for the analysis of noscapine, both as a bulk drug and in its formulation. The method employed TLC aluminium plates precoated with silica gel 60F‐254 as the stationary phase.
Ahmed, Ashour, Maha Abdel Monem, Hegazy, Azza Aziz, Moustafa, Khadiga Omar, Kelani, Laila Elsayed Abdel, Fattah   +4 more
openaire   +2 more sources

Stability-indicating methods for the determination of doxazosin mezylate and celecoxib

Journal of Pharmaceutical and Biomedical Analysis, 2002
Two stability-indicating methods were developed for the determination of doxazosin mesylate (I) and celecoxib (II) in the presence of their degradation products. The first method depends on the use of first derivative spectrophotometry (D(1)) at 256, 269 nm for (I) and (II), respectively. This method determines (I) and (II) in concentration ranges of 0.
L I, Bebawy, A A, Moustafa, N F, Abo-Talib   +2 more
openaire   +2 more sources

Stability-Indicating Spectrofluorimetric Method for the Assay of Ziprasidone in Capsules

Journal of Fluorescence, 2011
A simple, rapid and highly sensitive spectrofluorimetric method was developed for determination of ziprasidone hydrochloride (ZPS) in capsules. The method is based on measuring the native fluorescence of ZPS in acetate buffer of pH 4.5 at 398 nm after excitation at 315 nm.
Mohamed I, Walash, Fathalla, Belal, Nahed, El-Enany, Manal, Eid, Rania N, El-Shaheny   +4 more
openaire   +2 more sources

Stability Indicating Method for SPf66 Antimalarial Peptide in Solution

Drug Development and Industrial Pharmacy, 2004
Stability studies on the SPf66 antimalarial peptide with different pH and temperature conditions were carried out. The degradation mechanism was elucidated by the size-exclusion chromatography (SEC) technique and the experimental data obtained at 37 degrees C and different pH were fitted to a kinetic degradation model that could explain the loss of its
A, Santoveña, M J, Dorta, A, Oliva, M, Llabrés, M E, Patarroyo, J B, Fariña   +5 more
openaire   +2 more sources

A Stability Indicating HPTLC Method for Pazopanib

Research Journal of Pharmaceutical Dosage Forms and Technology
Pazopanib is a drug used for the treatment of advanced renal cell cancer and advanced soft tissue sarcoma (in patients previously treated with chemotherapy). An extensive literature search revealed some methods reported based on RP-HPLC but HPTLC method was not reported. Since there was no HPTLC method published for the stability studies and literature
Mrinalini Damle, Mrunmayi Pokharkar, Pallavi Kapratvar   +2 more
openaire   +1 more source

LC method for telithromycin in tablets: A stability-indicating assay

International Journal of Pharmaceutics, 2009
A liquid chromatographic (LC) method for the quantitative determination of telithromycin, the first member of the ketolides, which is a new class of macrolides, was developed. Analytical parameters were studied according to International Conference on Harmonization (ICH) guidelines.
Lauren C, Vaucher, Clésio S, Paim, Alini D, Lange, Elfrides E S, Schapoval   +3 more
openaire   +2 more sources