Results 51 to 60 of about 2,711,184 (322)
Inventions, 2023 This study presents the manufacturing process-driven development of an interlocking metasurface; (ILM) mechanism for fused filament fabrication; (FFF) with a focus on open-source accessibility.
Philip Gloyer +4 more
doaj +1 more source
Diphthamide synthesis is linked to the eEF2‐client chaperone machinery
FEBS Letters, EarlyView.The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr +4 more
wiley +1 more source
Journal of High Energy Physics, 2020 Abstract AdS7 supersymmetric solutions in type IIA have been classified, and they are infinitely many. Moreover, every such solution has a non-supersymmetric sister. In this pa- per, we study the perturbative and non-perturbative stability of these non-supersymmetric solutions, focusing on cases without orientifolds. Perturbatively,
Apruzzi F. +4 more
openaire +9 more sources
Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase
FEBS Letters, EarlyView.Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka +6 more
wiley +1 more source
Specialized interfaces of Smc5/6 control hinge stability and DNA association
Nature Communications, 2017 Structural Maintenance of Chromosomes (SMC) complexes maintain genome integrity by regulating the segregation of chromosomes. Here, Altet al. describe the structure of the heterodimeric Smc5/6-hinge from fission yeast and define functional features ...
Aaron Alt +10 more
doaj +1 more source
Reorganization of Cell Compartmentalization Induced by Stress
Biomolecules, 2022 The discovery of intrinsically disordered proteins (IDPs) that do not have an ordered structure and nevertheless perform essential functions has opened a new era in the understanding of cellular compartmentalization.
Anna S. Fefilova +5 more
doaj +1 more source
Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions
FEBS Letters, EarlyView.This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten +10 more
wiley +1 more source
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, EarlyView.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source
Secondary Homological Stability for Unordered Configuration Spaces [PDF]
arXiv, 2021 Secondary homological stability is a recently discovered stability pattern for the homology of a sequence of spaces exhibiting homological stability in a range where homological stability does not hold. We prove secondary homological stability for the homology of the unordered configuration spaces of a connected manifold.
arxiv