Results 71 to 80 of about 8,363,118 (322)

Osmotic disruption of chromatin induces Topoisomerase 2 activity at sites of transcriptional stress

Nature Communications
Transcription generates superhelical stress in DNA that poses problems for genome stability, but determining when and where such stress arises within chromosomes is challenging. Here, using G1-arrested S.
William H. Gittens, Rachal M. Allison, Ellie M. Wright, George G. B. Brown, Matthew J. Neale   +4 more
doaj   +1 more source

TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription

Nature Communications, 2017
DNA double-strand breaks (DSBs) induced by topoisomerase II (TOP2) are rejoined by TDP2-dependent non-homologous end-joining (NHEJ) but whether this promotes or suppresses translocations is not clear. Here the authors show that TDP2 suppresses chromosome
Fernando Gómez-Herreros, Guido Zagnoli-Vieira, Ioanna Ntai, María Isabel Martínez-Macías, Rhona M. Anderson, Andrés Herrero-Ruíz, Keith W. Caldecott   +6 more
doaj   +1 more source

EU Fiscal Rules: A Look Back and the Way Forward

Intereconomics, 2022
The decline of “natural real interest rates” during the last three decades is a common phenomenon in all advanced economies and can be explained by a number of structural factors: the downward trend in potential growth; population ageing, which has led ...
Klaus Regling
doaj   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Inhibition of topoisomerase 2 catalytic activity impacts the integrity of heterochromatin and repetitive DNA and leads to interlinks between clustered repeats

Nature Communications
DNA replication and transcription generate DNA supercoiling, which can cause topological stress and intertwining of daughter chromatin fibers, posing challenges to the completion of DNA replication and chromosome segregation.
Michalis Amoiridis, John Verigos, Karen Meaburn, William H. Gittens, Tao Ye, Matthew J. Neale, Evi Soutoglou   +6 more
doaj   +1 more source

Selection, Stability and Renormalization

, 1993
We illustrate how to extend the concept of structural stability through applying it to the front propagation speed selection problem. This consideration leads us to a renormalization group study of the problem.
Andronov, Aronson, Bahiana, Ben-Jacob, Bender, Bricmont, Carr, Carr, Carr, Chakrabarti, Chen, Chen, Dee, Dee, Dee, Ginzburg, Glenn Paquette, Goldenfeld, Goldenfeld, goldenfeld, goldenfeld, Goldenfeld, Helfand, Kametaka, Kevorkian, Kolmogorov, Kuramoto, Langer, Leibler, Lin-Yuan Chen, Liu, Murdock, Newell, Nigel Goldenfeld, Ohta, Oono, Oono, Oono, Oono, Oono, Oono, Paquette, Paquette, Peixoto, Peixoto, Roberts, Shub, Shub, Smith, Stokes, Taniuti, Taniuti, van Saarloos, Weinberger, Wilson, Wilson, Wilson, Y. Oono, Zinn-Justin   +58 more
core   +1 more source

Hydrated Eutectic Electrolyte with Ligand‐Oriented Solvation Shell to Boost the Stability of Zinc Battery [PDF]

, 2022
Mingming Han, Jiwu Huang, Xuesong Xie, Tianchen Li, Jiangtao Huang, Shuquan Liang, Jiang Zhou, Hong Jin Fan   +7 more
openalex   +1 more source

OnD-stability andB-stability

Numerische Mathematik, 1983
In this paper theD-stability properties of some classes of perturbed collocation methods are investigated. Among others we show the implicit Runge-Kutta methods described by Ehle-Chipman to beD-stable. We also give implicit Runge-Kutta methods that are bothD-stable andA-stable but notB-stable.
openaire   +1 more source

The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells

FEBS Letters, EarlyView.
The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman, Annika Egeler, Saskia Rödl, Johannes M. Herrmann   +3 more
wiley   +1 more source

PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2

Nature Communications, 2016
Chromosomal single-strand DNA breaks occur frequently and require repair to avoid disease outcomes. Here, the authors show that in bird cells, PARP3 accelerates this repair, and use structural biology and cell biology techniques to reveal details of the ...
Gabrielle J. Grundy, Luis M. Polo, Zhihong Zeng, Stuart L. Rulten, Nicolas C. Hoch, Pathompong Paomephan, Yingqi Xu, Steve M. Sweet, Alan W. Thorne, Antony W. Oliver, Steve J. Matthews, Laurence H. Pearl, Keith W. Caldecott   +12 more
doaj   +1 more source