Results 111 to 120 of about 2,331,184 (299)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
MATEC Web of Conferences, 2017 The paper deals with the assessment of slope stability on the road II/595 near the village Zlatno before and after the landslide caused by floods in 2010. The calculation of factor of safety was made using GEO 5 software.
Harabinova Slavka, Panulinova Eva
doaj +1 more source
Brazil: Financial System Stability Assessment
IMF Staff Country Reports, 2012 The paper discusses the stability of Brazil's financial system, which is diversified and shows sustained economic progress. Fiscal and monetary policies have been aimed to improve bank reserves, and foreign exchange intervention has been streamlined to curb volatility in the exchange market. These measures have been effective in achieving the immediate
openaire +2 more sources
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
New Generation Stability Norms – How to Approach the Task
Polish Maritime Research, 2018 International stability norms included in the Code of Intact Stability 2008 adopted by IMO on 4 December 2008 constitutes the latest set of international requirements on intact stability of ships.
Kobyliński Lech
doaj +1 more source
Practical reliability-based calculation tool for the post-fire assessment of concrete beams [PDF]
, 2015 If a structure has been able to maintain stability during fire exposure, the residual load-bearing capacity of the structural elements after fire should be determined when deciding upon the further use of the structure. Since adequate safety is a primary
Caspeele, Robby +2 more
core +1 more source
Chad: Financial Sector Stability Assessment
IMF Staff Country Reports, 2011 The financial stability of Chad is analyzed in this study. Chad's financial system is one of the least developed in the CEMAC region. Chad’s financial system is highly dependent on oil and agriculture, since it is a low-income country. In structuring the financial sector, the soundness and performance, short-term vulnerabilities, and supervision and ...
openaire +3 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
The Effect of Stone Class I Characteristics on Hydraulic Stability of Multi-Layer Berm Breakwaters
نشریه مهندسی دریا, 2020 Assessing the stability of the breakwaters against incident waves is the most important issue in structure designing. Due to this fact, the effects of different parameters on the stability of multi-layer berm breakwater (MLBBs) have been presented in ...
Majid Ehsani +2 more
doaj
How to get the Blanchard-Kahn form from a general linear rational expectations model [PDF]
, 1996 In this paper, we prove that every linear model with rational expectations can be transformed by the means of an one-to-one mapping into another model which has one of the following properties: i) it is degenerated, ii) it is backward, ii) it has the ...
Boucekkine, Raouf +2 more
core +1 more source