Results 241 to 250 of about 2,700,096 (301)

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

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Evaluation of walking stability

2010 IEEE 23rd International Symposium on Computer-Based Medical Systems (CBMS), 2010
We assessed walking stability, using a portable acceleration measurement system. We measured the acceleration displacement at the center of gravity (COG) of a normal walking subject and evaluated walking stability. We noted the dispersion of high and low acceleration at the COG that is a factor of walking stability.
Yuriko Tsuruoka, Masako Tsuruoka, Ryosuke Shibasaki   +2 more
openaire   +1 more source

Evaluation of Knee Stability and Stabilizing Systems

Radiology, 1967
Knee injuries are a major problem in competitive contact sports. During the past two years, the Radiology Department and the Sports Medicine Section of Orthopedic Surgery have been evaluating knee stability before and after knee surgery. For this purpose, tape recording of television fluoroscopy has been used.
A C, Kittleson, G A, O'Connor, H P, Rodriguez   +2 more
openaire   +2 more sources

Evaluating evaluation measure stability

Proceedings of the 23rd annual international ACM SIGIR conference on Research and development in information retrieval, 2000
This paper presents a novel way of examining the accuracy of the evaluation measures commonly used in information retrieval experiments. It validates several of the rules-of-thumb experimenters use, such as the number of queries needed for a good experiment is at least 25 and 50 is better, while challenging other beliefs, such as the common evaluation ...
Chris Buckley, Ellen M. Voorhees
openaire   +1 more source

Standardized evaluation of protein stability

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2010
We compare mean force potential values of a large series of PDB models of proteins and peptides and find that, either as monomers or polymers, proteins longer than 200-250 residues have equivalent MFP values that are averaged to -65+/-3 kcal/aa. This value is named the standard or stability value. The standard value is reached irrespective of sequences
Thomas, Annick, Joris, Bernard, Brasseur, Robert   +2 more
openaire   +2 more sources

Performance evaluations of quantized stabilizers

42nd IEEE International Conference on Decision and Control (IEEE Cat. No.03CH37475), 2004
We propose different feedback quantized stabilization strategies for input-state linear systems and we analyze their performances in terms of number of required quantization levels versus the convergence time they yield.
F. Fagnani, ZAMPIERI, SANDRO
openaire   +1 more source