Results 41 to 50 of about 3,340,940 (292)

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

On stability of an optimal situation in a finite cooperative game with a parametric concept of equilibrium (from lexicographic optimality to Nash equilibrium) [PDF]

Computer Science Journal of Moldova, 2005
A parametric concept of equilibrium (principle of optimality) in a finite cooperative game in normal form of several players is introduced. This concept is defined by means of the partition of players into coalitions.
Sergey E. Bukhtoyarov, Vladimir A. Emelichev   +1 more
doaj  

On Some Sufficiency-Type Stability and Linear State-Feedback Stabilization Conditions for a Class of Multirate Discrete-Time Systems

Mathematics, 2018
This paper presents and discusses the stability of a discrete multirate sampling system whose sets of sampling rates (or sampling periods) are the integer multiple of those operating on all the preceding substates.
M. De la Sen
doaj   +1 more source

Modeling Car-Following Behaviour of Turning Movements at Intersections with Consideration of Turning Radius

Journal of Advanced Transportation, 2020
In order to deeply analyze and describe the characteristics of car-following behaviour of turning vehicles at intersections, the features and application conditions of classic car-following models were analyzed firstly.
Fulu Wei, Yongqing Guo, Pan Liu, Zhenggan Cai, Qingyin Li, Long Chen   +5 more
doaj   +1 more source

Elderly unstable distal radius fractures a prospective cohort study of bone substitutes-augmented percutaneous pinning

BMC Musculoskeletal Disorders, 2022
Highlights 1- When used to augment percutaneous pinning of elderly unstable distal radius fractures, bone substitutes did not significantly offer additional postoperative mechanical stability of fixation construct.
Amr Abdel-Mordy Kandeel
doaj   +1 more source

Warped Supersymmetric Radius Stabilization

, 2004
A simple model of extra-dimensional radius stabilization in a supersymmetric Randall-Sundrum model is presented. In our model, we introduce only a bulk hypermultiplet and source terms on each boundary branes. With an appropriate choice of model parameters, we find that the radius can be stabilized by supersymmetric vacuum conditions.
Maru, Nobuhito, Okada, Nobuchika
openaire   +2 more sources

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

Casimir effect on the radius stabilization of the noncommutative torus [PDF]

Physics Letters B, 2001
We evaluate the one-loop correction to the spectrum of Kaluza-Klein system for the $ ^3$ model on $R^{1,d}\times (T_ ^2)^L$, where $1+d$ dimensions are the ordinary flat Minkowski spacetimes and the extra dimensions are the L two-dimensional noncommutative tori with noncommutativity $ $.
openaire   +4 more sources

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

Expanding Hereditary Spastic Paraplegias Limits: Biallelic SPAST Variants in Cerebral Palsy Mimics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegias (HSP) are rare neurodegenerative disorders marked by spasticity and lower limb weakness. The most common type, SPG4, is usually autosomal dominant and caused by SPAST gene variants, typically presenting as pure HSP.
Gregorio A. Nolasco, Mònica Roldán, Yalda Jamshidi, Ioannis Georvasilis, Rocío Jadraque Rodríguez, Reza Boostani, Ali Shoeibi, Lluís Armengol, Anna Codina, Ehsan Ghayoor Karimiani, Cristina Hernando‐Davalillo, Loreto Martorell, María Luisa Ramírez Almaraz, Jordi Muchart, Carlos Ortez, Andrés Nascimento, Roser Urreizti, Daniel Natera‐de Benito, Mercedes Serrano   +18 more
wiley   +1 more source