Results 71 to 80 of about 637,963 (247)

Computing Solution Operators of Boundary-value Problems for Some Linear Hyperbolic Systems of PDEs

open access: yes, 2017
We discuss possibilities of application of Numerical Analysis methods to proving computability, in the sense of the TTE approach, of solution operators of boundary-value problems for systems of PDEs.
Selivanov, Victor, Selivanova, Svetlana
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Difference schemes of high accuracy for a Sobolev-type pseudoparabolic equation

open access: yesҚарағанды университетінің хабаршысы. Математика сериясы
In this work, numerical algorithms of higher-order accuracy are constructed and studied for a pseudoparabolic equation that describes the filtration process in fractured-porous media.
M.M. Aripov   +2 more
doaj   +1 more source

Nash Equilibrium and Robust Stability in Dynamic Games: A Small-Gain Perspective [PDF]

open access: yes
This paper develops a novel methodology to study robust stability properties of Nash equilibrium points in dynamic games. Small-gain techniques in modern mathematical control theory are used for the first time to derive conditions guaranteeing uniqueness
Athanasiou, George   +2 more
core   +1 more source

Rosenbrock-Krylov Methods for Large Systems of Differential Equations

open access: yes, 2014
This paper develops a new class of Rosenbrock-type integrators based on a Krylov space solution of the linear systems. The new family, called Rosenbrock-Krylov (Rosenbrock-K), is well suited for solving large scale systems of ODEs or semi-discrete PDEs ...
Sandu, Adrian, Tranquilli, Paul
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Periodicity in distribution. I. Discrete systems

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2002
We consider the existence of periodic in distribution solutions to the difference equations in a Banach space. A random process is called periodic in distribution if all its finite-dimensional distributions are periodic with respect to shift of time with
A. Ya. Dorogovtsev
doaj   +1 more source

Spurious frequencies as a result of numerical boundary treatments [PDF]

open access: yes
The stability theory for finite difference Initial Boundary-Value approximations to systems of hyperbolic partial differential equations states that the exclusion of eigenvalues and generalized eigenvalues is a sufficient condition for stability.
Abarbanel, Saul, Gottlieb, David
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

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