Results 61 to 70 of about 87,122,171 (238)

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Difference inequality for stability of impulsive difference equations with distributed delays

Journal of Inequalities and Applications, 2011
In this paper, we consider a class of impulsive difference equations with distributed delays. By establishing an impulsive delay difference inequality and using the properties of "ρ-cone" and eigenspace of the spectral radius of non-negative ...
Long Shujun, Li Dingshi, Wang Xiaohu
doaj  

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Stability calculations for piecewise-smooth delay equations [PDF]

, 2008
This paper describes a new method for computing the stability of nonsmooth periodic orbits of piecewise-smooth dynamical systems with delay. Stability computations for piecewise-smooth dynamical systems without delay have previously been performed using ...
Barton, DAW
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Asymptotic Stability for the 2D Navier–Stokes Equations with Multidelays on Lipschitz Domain

, 2022
This paper is concerned with the asymptotic stability derived for the two-dimensional incompressible Navier–Stokes equations with multidelays on Lipschitz domain, which models the control theory of 2D fluid flow.
Ling-Rui Zhang, Ke-Qin Su, Xin-Guang Yang   +2 more
core   +1 more source

Existence and Global Exponential Stability of Pseudo Almost Periodic Solutions for Neutral Type Quaternion-Valued Neural Networks with Delays in the Leakage Term on Time Scales

Complexity, 2017
We propose a class of neutral type quaternion-valued neural networks with delays in the leakage term on time scales that can unify the discrete-time and the continuous-time neural networks. In order to avoid the difficulty brought by the noncommutativity
Yongkun Li, Xiaofang Meng
doaj   +1 more source