Results 71 to 80 of about 2,053,721 (364)
Fundamentals of soil stabilization
International Journal of Geo-Engineering, 2017 Clayey soils are usually stiff when they are dry and give up their stiffness as they become saturated. Soft clays are associated with low compressive strength and excessive settlement. This reduction in strength due to moisture leads to severe damages to
A. A. Firoozi +3 more
semanticscholar +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Application of Lignin for Slope Bioengineering: Effect on Soil Improvement and Plant Growth
Applied SciencesThis study aims to establish whether lignin-treated soils could result in greater soil strength and stimulate seed germination and growth, which can be essential for slope bioengineering. Three different soil types with a range of plasticity were treated
Ivan Gratchev +3 more
doaj +1 more source
Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
Nature Communications, 2016 Extracellular interaction between programmed death ligand-1 (PD-L1) and programmed cell death protein-1 (PD-1) leads to tumour-associated immune escape. Here we show that the immunosuppression activity of PD-L1 is stringently modulated by ubiquitination ...
Chia‐Wei Li +23 more
semanticscholar +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11
Cancer Research, 2019 Although cell cycle arrest, senescence, and apoptosis are established mechanisms of tumor suppression, accumulating evidence reveals that ferroptosis, an iron-dependent, non-apoptotic form of cell death, represents a new regulatory pathway in suppressing
Tong Liu, Le Jiang, O. Tavana, W. Gu
semanticscholar +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Uncertainty factor in modeling dynamics of economic systems [PDF]
Компьютерные исследования и моделирование, 2018 Analysis and practical aspects of implementing developed in the control theory robust control methods in studying economic systems is carried out. The main emphasis is placed on studying results obtained for dynamical systems with structured uncertainty.
Leonid E. Varshavsky
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Pharmacokinetic study of a new 4,5-dihydroisoxazole-5-carboxamide derivative in rats
Разработка и регистрация лекарственных средствIntroduction. 3-(2-butyl-5-chloro-1H-imidazole-4-yl)-N-[4-methoxy-3-(trifluoromethyl)phenyl]-4,5-dihydro-1,2-oxazole-5-carboxamide (R004) is a prospective new molecule for the treatment of rheumatoid arthritis.
I. I. Yaichkov +6 more
doaj +1 more source