Advanced Science, EarlyView.The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi +8 more
wiley +1 more source
Colorectal cancer as a complex adaptive system: integrating the hallmarks of cancer with complexity theory. [PDF]
Front OncolBasbus LR.
europepmc +1 more source
On the Stability of the Discontinuous Feedback Systems
Journal of The Society of Instrument and Control Engineers, 1970 MAEDA, Hajime +2 more
openaire +1 more source
Advanced Science, EarlyView.When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley +1 more source
Matrifibrocytes Redefine Cardiac Fibrosis: From Terminal Differentiation to Translational Modulation. [PDF]
J Cell Mol MedZhang Z, Zhu H.
europepmc +1 more source
A Ku-Band 13 W GaN HEMT Power Amplifier MMIC with a Coupled-Line Interstage Stabilization Technique for Radar Sensor Systems. [PDF]
Sensors (Basel)Kim J.
europepmc +1 more source
The fibrosis-plasticity axis (FPA) and ionic resilience: a systems framework for understanding adverse drug reactions in ageing populations. [PDF]
Front PharmacolCarballo A.
europepmc +1 more source
Behavioral Dentistry in the Digital Age: A Review of Biofeedback Occlusal Splint Therapy. [PDF]
CureusChipper A +5 more
europepmc +1 more source
Noise-Limited Failure of OGY Chaos Control in Regulating Monosynaptic Reflex Variability in the In Vivo Cat Spinal Cord. [PDF]
NeuroSciManjarrez E +3 more
europepmc +1 more source