Results 71 to 80 of about 63,499 (283)

Efficacy and Safety of Dupilumab in Chinese Adult Patients With Chronic Rhinosinusitis With Nasal Polyps: A Randomized, Placebo‐Controlled, Phase III Trial

open access: yesAllergy, EarlyView.
Dupilumab significantly improved nasal polyp score, nasal congestion, olfaction, total symptom score, and disease‐specific quality of life in Chinese patients with uncontrolled CRSwNP. Incidence of treatment‐emergent adverse events was similar between dupilumab and placebo.
Mu Xian   +18 more
wiley   +1 more source

TAURIN INFLUENCE ON CLINICAL COURSE OF STAbLE ANGINA IN POSTINFARCTION  CARDIOSCLEROSIS PATIENTS

open access: yesРоссийский кардиологический журнал, 2018
Aim. Study of efficacy and safety of taurin in management of stable angina patients with postinfarction cardiosclerosis.Material and methods. Totally, 95 postinfarction cardiosclerosis patients included, with stable angina of II and III functional class.
I. S. Vasilieva, V. V. Rezvan
doaj   +1 more source

Marked variation in eligibility criteria across registrational trials for relapsed diffuse large B‐cell lymphoma limits applicability to clinical practice

open access: yesBritish Journal of Haematology, EarlyView.
Summary Therapeutic options for relapsed or refractory diffuse large B‐cell lymphoma (rDLBCL) have expanded following accelerated approvals based largely on surrogate end‐points, yet confirmatory studies have not consistently reproduced these benefits across all agents, and outcomes for many patients remain poor.
Elizabeth Goodall   +11 more
wiley   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

open access: yesBritish Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

The Peculiarities of the Endothelial Function, Blood Lipid Spectrum and Heart Rate Variability in Patients with Stable Angina, Depending on the Heart Rate Frequency

open access: yes, 2016
The survey studies the impact of heart rate on the development of endothelial dysfunction and disorders of heart rate variability in patients with stable angina. Introduction.
Аbrahamovych О., Bilous Z.
core   +1 more source

The Effects of Combined Antihypertensive and Antidiabetic Therapies on Cardiovascular Outcomes: A Systematic Review and Meta‐Analysis

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Hypertension and diabetes frequently coexist, yet the net clinical impact of intentionally combining antihypertensive (AHTN) and antidiabetic (ADA) therapies on cardiovascular (CV) outcomes is uncertain. Here we quantified the effects of AHTN and ADA co‐therapy on CV and blood pressure (BP)/heart rate (HR) outcomes.
Wan Chin Hsieh   +2 more
wiley   +1 more source

Acute coronary syndrome in diclofenac sodium-induced type I hypersensitivity reaction : Kounis syndrome [PDF]

open access: yes, 2007
Drug-induced type I hypersensitivity reactions are frequent. Sometimes, acute coronary syndrome (ACS) can be registered in such patients, which may have a serious impact on the course and management of the allergic reaction.
Panic, Milos   +5 more
core  

Left Ventricular Remodeling in Patients with Stable Angina Complicated by Heart Failure with Reduced and Preserved Ejection Fraction

open access: yes, 2016
Introduction. Chronic heart failure is one of the most common and serious diseases of cardiovascular system, resulting in permanent disability and significantly reducing the length and quality of life.
Muzyka N., Denesyuk V., Denesyuk O.
core   +1 more source

What Is a Clinically Meaningful Change in Diabetes Distress? Findings for Diabetes Care and Research From the SFDT1 Cohort

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Diabetes distress (DD) is common and evolves heterogeneously over time. We aimed to estimate minimal clinically important differences (MCID) for the Problem Areas in Diabetes (PAID) scale and its sub‐dimensions and to identify predictors of worsening over 1 year in people with type 1 diabetes (PwT1D).
Dulce Canha   +10 more
wiley   +1 more source

Prognosis of angina with and without a diagnosis: 11 year follow up in the Whitehall II prospective cohort study

open access: yes, 2003
Objective: To investigate the prognosis of angina among people with and without diagnosis by a doctor and an abnormal cardiovascular test result. Design: Prospective cohort study with a median follow up of 11 years.
Shipley, M.   +11 more
core  

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