Results 161 to 170 of about 2,136,124 (276)

Astrocytic Ketogenesis Protects Central Nervous System Injury via CPT1A Stabilization and Epigenetic Regulation

Advanced Science, EarlyView.
A distinct astrocyte subpopulation, enriched at the lesion border, drives CNS repair through enhanced ketone body metabolism. This process promotes neuronal survival and axonal sparing via CPT1A stabilization and H3K9bhb‐dependent epigenetic reprogramming, positioning astrocytic ketogenesis as a promising therapeutic target for tissue regeneration ...
Dishui Pan, Haoming Shu, Rui Gao, Yilong Ren, Wu Ye, Xuhui Ge, Yao Gu, Yufeng Zhu, Xiaokun Wang, Honglin Teng, Xuhui Zhou, Wei Liu, Yang Gao, Jianquan Zhao, Weihua Cai   +14 more
wiley   +1 more source

Virome DNA stable isotope probing reveals diverse active soil virus communities across ecosystem contexts. [PDF]

mSystems
Osburn ED, Kim M.
europepmc   +1 more source

Quantitative Stable-Isotope Probing (qSIP) with Metagenomics Links Microbial Physiology and Activity to Soil Moisture in Mediterranean-Climate Grassland Ecosystems. [PDF]

mSystems, 2022
Greenlon A, Sieradzki E, Zablocki O, Koch BJ, Foley MM, Kimbrel JA, Hungate BA, Blazewicz SJ, Nuccio EE, Sun CL, Chew A, Mancilla CJ, Sullivan MB, Firestone M, Pett-Ridge J, Banfield JF.   +15 more
europepmc   +1 more source

Neutron Depth Profiling: The Core Link Connecting the Microscopic Mechanisms of Lithium‐Ion Batteries With Intelligent Design

Advanced Science, EarlyView.
Neutron depth profiling exploits the 6Li(n,3H)4He reaction to provide quantitative, isotope‐specific, depth‐resolved maps of lithium inside operating lithium‐ion batteries, directly linking lithium transport, dendrite growth and interfacial short‐circuiting to a physics‐informed machine‐learning roadmap that turns this non‐destructive operando ...
Yulong Zhang, Chunjing Yue, Shijiao Liu, Muyang Chen, Xiaokang Shi, Rui Tan, Hongqing Hao, Jie Yang, Xinhua Liu   +8 more
wiley   +1 more source

HT-SIP: a semi-automated stable isotope probing pipeline identifies cross-kingdom interactions in the hyphosphere of arbuscular mycorrhizal fungi. [PDF]

Microbiome, 2022
Nuccio EE, Blazewicz SJ, Lafler M, Campbell AN, Kakouridis A, Kimbrel JA, Wollard J, Vyshenska D, Riley R, Tomatsu A, Hestrin R, Malmstrom RR, Firestone M, Pett-Ridge J.   +13 more
europepmc   +1 more source

Lactate Homeostasis Disruption Potentiates TACE‐Immunotherapy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Lactate homeostasis is disrupted through spatially coordinated extracellular neutralization and intracellular acidification, triggering calcium overload, mitochondrial dysfunction, and immunogenic cell death. This metabolic reprogramming alleviates the immunosuppressive tumor microenvironment and enhances immune checkpoint blockade, providing a ...
Minjiang Chen, Xiaoxiao Chen, Baozhu Yang, Hui Xu, Xueting Sun, Hongkai Qi, Huilin Hu, Ronghua Wu, Fengkai Qiu, Bing Wu, Yu Luo, Gaofeng Shu, Jiansong Ji   +12 more
wiley   +1 more source

Population Dynamics and Cross-Feeding in an Antibiotic-Degrading Synthetic Ecosystem: Insights from Single-Cell Raman Spectroscopy and Stable Isotope Probing. [PDF]

Environ Sci Technol Lett
Xue R, Wu X, Ji R, Lin L, Yang K, Corvini PF, Cui L, Zhu YG, Li HZ.   +8 more
europepmc   +1 more source

RNA-based stable isotope probing provides no indication for rapid α-synuclein assimilation by murine gut bacteria. [PDF]

Access Microbiol, 2022
Brandau L, Weis S, Weyland M, Berger FK, Schnell S, Schäfer KH, Egert M.   +6 more
europepmc   +1 more source

Tip60‐Mediated USP22 Lactylation Drives Glutamine Metabolic Reprogramming via SLC25A5 in TNBC

Advanced Science, EarlyView.
Tip60‐mediated USP22 K134 lactylation, stabilizing SLC25A5 to enhance glutamine metabolism and α‐KG secretion. The secreted α‐KG drives GPR91‐dependent M2 macrophage polarization, promoting triple‐negative breast cancer progression. Targeting this axis synergizes with CB‐839, offering a promising therapeutic strategy for TNBC.
Fang Zhen, Hongyi Wang, Ningzhi Zhang, Le Wang, Huiyuan Tian, Luxi Kang, Zhanpeng Liu, Jing Hu   +7 more
wiley   +1 more source

DNA stable isotope probing reveals hidden microbial carbon processing pathways in agricultural soils. [PDF]

Appl Environ Microbiol
Tfaily MM.
europepmc   +1 more source