Results 91 to 100 of about 236,951 (263)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Designing for diversity: team formation and participatory policy design

Policy Design and Practice
Participatory policy design benefits from tools that engage diverse voices. One emerging tool is the civic hackathon, which brings together diverse participants to co-develop policy ideas.
Debra Hevenstone, Nada Endrissat, Oleg Lavrovsky, Oliver Hümbelin   +3 more
doaj   +1 more source

Stable Multicommodity Flows

Algorithms, 2013
We extend the stable flow model of Fleiner to multicommodity flows. In addition to the preference lists of agents on trading partners for each commodity, every trading pair has a preference list on the commodities that the seller can sell to the buyer. A
Tamás Király, Júlia Pap
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Network Selection Algorithm Based on Stable Matching Game in Vehicular Heterogeneous Network

Dianxin kexue, 2015
A gaming method of vehicular heterogeneous network selection was proposed, to solve the network access problem of vehicles in heterogeneous network coverage.
Rui Zhang, Jing Hu, Weiwei Xia
doaj   +2 more sources

Two-Stage Stable Matching Based Dynamic Spectrum Allocation in Heterogeneous Networks

IEEE Access, 2019
This paper addresses the resource allocation problem for small cells in the two-tier heterogeneous networks (HetNets) with non-independent resource blocks (RBs) usability, which is prevalent in HetNets application.
Jianzhao Zhang, Yong Chen, Yongxiang Liu, Tao Zhang   +3 more
doaj   +1 more source

The Stable Matching Problem in TBEV Enzootic Circulation: How Important Is the Perfect Tick-Virus Match? [PDF]

Microorganisms, 2021
Liebig K, Boelke M, Grund D, Schicht S, Bestehorn-Willmann M, Chitimia-Dobler L, Dobler G, Jung K, Becker SC.   +8 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Characterization of Dynamics of Stable Matchings: Attractors Mapped from Stable Matchings

Procedia Computer Science, 2013
AbstractThis note characterizes the dynamic structure of stable matchings of the stable marriage problem (SMP). The characterization focuses on the dynamic process of how the stable matching will be attained. To this end, the discrete problem of the SMP will be mapped to nonlinear dynamical models whose attractors include the counterparts of the stable
Yoshiteru Ishida, Takumi Satou
openaire   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source