Results 71 to 80 of about 972,187 (291)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
International Journal of Computational Intelligence Systems, 2022 Driven by the development of platform economy, two-sided matching decision-making (TSDM) has become one of the most important applications in the field of intelligent computation system. Many recommendation systems based on TSDM have facilitated our life.
Junchang Qin +4 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Mechanism Design without Money via Stable Matching [PDF]
, 2011 Mechanism design without money has a rich history in social choice literature. Due to the strong impossibility theorem by Gibbard and Satterthwaite, exploring domains in which there exist dominant strategy mechanisms is one of the central questions in ...
Chen, Ning, Gravin, Nick, Lu, Pinyan
core
Solving stable matching problems using answer set programming [PDF]
, 2015 Since the introduction of the stable marriage problem (SMP) by Gale and Shapley (1962), several variants and extensions have been investigated. While this variety is useful to widen the application potential, each variant requires a new algorithm for ...
De Clercq, Sofie +3 more
core +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Counting Houses of Pareto Optimal Matchings in the House Allocation Problem [PDF]
, 2016 Let $A,B$ with $|A| = m$ and $|B| = n\ge m$ be two sets. We assume that every element $a\in A$ has a reference list over all elements from $B$. We call an injective mapping $\tau$ from $A$ to $B$ a matching. A blocking coalition of $\tau$ is a subset $A'$
Asinowski, Andrei +2 more
core +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source