Results 41 to 50 of about 195,724 (266)
CrystalsThe crystal structures of the 2-amino-5-halogenopyridines (halogen = Cl (1), Br (2)) and 2,3-diamino-5-halogenopyridines (halogen = Cl (3), Br (4)) were compared with respect to their intermolecular interactions.
Irina S. Konovalova, Guido J. Reiss
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
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Hybrid Machine Learning Model for Efficient Botnet Attack Detection in IoT Environment
IEEE AccessCyber attacks are growing with the rapid development and wide use of internet technology. Botnet attack emerged as one of the most harmful attacks. Botnet identification is becoming challenging due to the numerous attack vectors and the ongoing evolution
Mudasir Ali +5 more
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Crystal Engineering and Molecular Architecture [PDF]
Fanāvarī-i āmūzish, 2007 The aim of this paper is to provide a link between research projects and education to optimize teaching and learning of related subjects. In a research project, three compounds including an intermolecular proton transfer compound, a hydrated carboxylic ...
H. Aghabozorg +4 more
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
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Advances in Mathematics, 2014 Let π: X -> S be a morphism of algebraic stacks that is locally of finite presentation with affine stabilizers. We prove that there is an algebraic S-stack, the Hilbert stack, parameterizing proper algebraic stacks mapping quasi-finitely to X. This was previously unknown, even for a morphism of schemes.
Hall, Jack, Rydh, David
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InformationThis study introduces BagStacking, an innovative ensemble learning framework designed to enhance the detection of freezing of gait (FOG) in Parkinson’s disease (PD) using accelerometer data.
Seffi Cohen +2 more
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Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
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