Results 61 to 70 of about 582,651 (294)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

BagStacking: An Integrated Ensemble Learning Approach for Freezing of Gait Detection in Parkinson’s Disease

Information
This study introduces BagStacking, an innovative ensemble learning framework designed to enhance the detection of freezing of gait (FOG) in Parkinson’s disease (PD) using accelerometer data.
Seffi Cohen, Nurit Cohen-Inger, Lior Rokach   +2 more
doaj   +1 more source

Stacking-fault energies for Ag, Cu, and Ni from empirical tight-binding potentials

, 2002
The intrinsic stacking-fault energies and free energies for Ag, Cu, and Ni are derived from molecular-dynamics simulations using the empirical tight-binding potentials of Cleri and Rosato [Phys. Rev. B 48, 22 (1993)].
A. Girshick, D. J. Oh, F. Cleri, J. A. Zimmerman, L. J. Lewis, M. J. Mehl, M. Parrinello, P. C. J. Gallagher, P. Heino, R. Meyer, W. G. Hoover   +10 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Optimization of Cocoa Pods Maturity Classification Using Stacking and Voting with Ensemble Learning Methods in RGB and LAB Spaces

Journal of Imaging
Determining the maturity of cocoa pods early is not just about guaranteeing harvest quality and optimizing yield. It is also about efficient resource management.
Kacoutchy Jean Ayikpa, Abou Bakary Ballo, Diarra Mamadou, Pierre Gouton   +3 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A stacking ensemble model for predicting the occurrence of carotid atherosclerosis

Frontiers in Endocrinology
BackgroundCarotid atherosclerosis (CAS) is a significant risk factor for cardio-cerebrovascular events. The objective of this study is to employ stacking ensemble machine learning techniques to enhance the prediction of CAS occurrence, incorporating a ...
Xiaoshuai Zhang, Chuanping Tang, Shuohuan Wang, Wei Liu, Wangxuan Yang, Di Wang, Qinghuan Wang, Fang Tang, Fang Tang, Fang Tang   +9 more
doaj   +1 more source

Stacking order dynamic in the quasi-two-dimensional dichalcogenide 1T-TaS$_2$ probed with MeV ultrafast electron diffraction

, 2017
Transitions between different charge density wave (CDW) states in quasi-two-dimensional materials may be accompanied also by changes in the inter-layer stacking of the CDW.
Chase, T., Dürr, H. A., Guyader, L. Le, Li, R. K., Mihailovic, D., Reid, A., Shen, X., Svetin, D., Vecchione, T., Wang, X. J.   +9 more
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source