Results 181 to 190 of about 3,792,137 (365)

A Self‐Assembling LYTAC Mediates CTGF Degradation and Remodels Inflammatory Tumor Microenvironment for Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
A CTGF‐LYTAC nanoplatform is developed to selectively degrade connective tissue growth factor (CTGF) in triple‐negative breast cancer (TNBC), inhibiting TGF‐β signaling and cell interactions in the tumor microenvironment (TME). This strategy effectively suppresses tumor growth and metastasis, outperforming antibody‐based therapy.
Jia‐Yi Lin, Ye Wu, Xiao‐Hui Liang, Min Tang, Xin Sun, Sheng‐Xin Lu, Jin‐Mei Jin, Xin Guo, Bei Wang, Hong‐Zhuan Chen, Wei‐Dong Zhang, Xin Luan   +11 more
wiley   +1 more source

Amplifying the value of the third space to support strategic curriculum change

Journal of Learning Development in Higher Education
This case study presents how we at Kingston University have expanded our collaborative ‘third space’ to support the delivery of an ambitious blueprint of skills development in the curriculum.
Annie Yonkers, Hilary Wason
doaj  

Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease

Advanced Science, EarlyView.
The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Haixia Su, Guoqing Wu, Muya Xiong, Yuhang Wang, Junyuan Cao, Mengyuan You, Yingchun Xiang, Tianqing Nie, Minjun Li, Gengfu Xiao, Leike Zhang, Qiang Shao, Yechun Xu   +12 more
wiley   +1 more source

Improvement critical care patient safety: using nursing staff development strategies, at Saudi Arabia. [PDF]

Glob J Health Sci, 2015
Basuni EM, Bayoumi MM.
europepmc   +1 more source

Creating Technology Staff Development Programs: A Leadership Perspective

, 1996
Dan Lumley, Gerald D. Bailey
openalex   +2 more sources

Atomic Layered ZnO Between Cu Nanoparticles and a PVP Polymer Layer Enable Exceptional Selectivity and Stability in Electrocatalytic CO2 Reduction to C2H4

Advanced Science, EarlyView.
Collaboration between Cu, ZnO, and PVP facilitates the electrochemical reduction of CO2. Abstract This study employs a chemically controlled strategy to construct a few‐atomic‐layer ZnO structure integrated with polyvinylpyrrolidone (PVP) and nanoscale metallic copper on active carbon.
Lihui Zhou, Hung‐Wei Tsai, Ting‐Wei Kuo, Jui‐Cheng Kao, Yu‐Chieh Lo, Ji‐Min Chang, Tzu‐Hsuan Chiang, Sheng Dai, Kuan‐Wen Wang, Tsan‐Yao Chen   +9 more
wiley   +1 more source

Editorial: Staff development in higher engineering education [PDF]

, 2001
Erik de Graaff, Anette Kolmos, Ole Vinther   +2 more
openalex   +1 more source

Potent Cross‐neutralizing Antibodies Reveal Vulnerabilities of Henipavirus Fusion Glycoprotein

Advanced Science, EarlyView.
Hendra and Nipah viruses (HNVs) pose significant threats to global health. This work reports potent cross‐neutralizing antibodies targeting the fusion glycoprotein (F) and reveals shared features of these antibodies and vulnerabilities of F, thereby guiding the rational design of countermeasures against HNVs and similar pathogens.
Yi Ren, Pengfei Fan, Xinghai Zhang, Ting Fang, Zhengshan Chen, Yanfeng Yao, Xiangyang Chi, Guanying Zhang, Xiaofan Zhao, Bingjie Sun, Fangxu Li, Zixuan Liu, Zhenwei Song, Baoyue Zhang, Cheng Peng, Entao Li, Yilong Yang, Jianmin Li, Sandra Chiu, Changming Yu   +19 more
wiley   +1 more source

Higher education staff development: a need-oriented approach based on survey research. [PDF]

Sci Rep
Zwolińska-Glądys K, Lorenc S, Kowalska N, Pomykała R.   +3 more
europepmc   +1 more source

Fully Automated Deep Learning Enabled Miniature Mass Spectrometry System for Psychoactive Therapeutic Drug Monitoring

Advanced Science, EarlyView.
This study presents a fully automated miniature mass spectrometry system for high‐throughput therapeutic drug monitoring. Integrating magnetic solid‐phase extraction, self‐aspiration sampling miniature mass spectrometer, and U‐net deep learning quantitative algorithm, it achieves rapid (8 samples/30 min), precise (R2 > 0.99, RSD < 10%), and portable ...
Yuanhao Zhou, Jiawen Ai, Zi Ye, Kexin Chen, JingXiong Lin, Zhenhua Zhang, Mi Luo, Benjie Zhou, Shijian Xiang, Jianhua Zhou, Xinming Huo   +10 more
wiley   +1 more source