Results 161 to 170 of about 863,776 (261)

Turning waiting time to action: co-designing solutions to support families waiting for appointments in an Australian metropolitan child development service. [PDF]

BMC Health Serv Res
Melvin K, Smith H, Dunstan K, Balfour-Ogilvy J, Benham C, Olsen J, O'Keefe A, Burn N, Aitchison D, Ware D, Folbigg S, Scarinci N, Armstrong R.   +12 more
europepmc   +1 more source

Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

Advanced Science, EarlyView.
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang, Shengxin Lu, Guangyong Zheng, Shensuo Li, Hongyu Chen, Mei Hong, Xiangru Zhou, Ruotian Tang, Ye Wu, Weidong Zhang, Dong Lu, Xin Luan   +11 more
wiley   +1 more source

Designing Artificial Intelligence Tools to Strengthen Human Connection in Healthcare: The CoCo Experience. [PDF]

J Patient Exp
Elias RM, Grimsley SM, Werneburg BL, Stevens SK, Kane S.   +4 more
europepmc   +1 more source

PANX2 Suppresses Lung Adenocarcinoma Progression by Inducing Disulfidptosis and Enhancing Antitumor Immunity

Advanced Science, EarlyView.
ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen, Zhao‐Yu Liu, Gao‐Wen Qu, Run‐Hao Zeng, Wen‐Xia Yao, Yong‐Bing Zhou, Xue Liang, Yu‐Xiong Lai   +7 more
wiley   +1 more source

Perceptions of Buprenorphine With Naloxone Treatment and the Fear of Precipitated Withdrawal: A Qualitative Exploration With HIV Prevention Trials Network 094 INTEGRA Participants and Staff. [PDF]

Drug Alcohol Rev
Schmidt RA, Perez-Brumer A, Davidson P, Shoptaw S, El-Bassel N, Andrew P, Harris J, Nieto O, Bornstein S, Redd R, Yeager J, Goodman-Meza D, Hasson AL, Seigel M, Denis C, El-Krab R, Smith LR, HPTN 094 Team.   +17 more
europepmc   +1 more source

ZDHHC17‐Mediated CDK4 Palmitoylation Drives Cell Cycle Progression and Orchestrates Cancer Immune Surveillance

Advanced Science, EarlyView.
ZDHHC17 palmitoylates CDK4, which together with TRAF6‐mediated ubiquitination, drives cell cycle progression and immune surveillance, revealing a rational combination of CDK4 inhibitors with immune checkpoint blockers for ZDHHC17‐driven cancers. ABSTRACT Uncontrolled cell cycle progression is a hallmark of cancer, tightly regulated by both intrinsic ...
Zekang Wang, Peipei Song, Xueji Wu, Lei Wang, Wei Xie, Pinning Feng, Chao Cheng, Jianping Guo   +7 more
wiley   +1 more source

Wide Temperature Zero Thermal Expansion in Al Matrix Composites with High Thermal Conductivity

Advanced Science, EarlyView.
Strain engineering strategy is implemented on the negative thermal expansion (NTE) phase Zn1.6Mg0.4P2O7 within composites, where Al matrix‐induced compressive strain drives uniform polyhedral and unit cell evolution, thereby enabling broad and consistent thermal compensation efficacy and obtaining good thermal performance.
Jinrui Qian, Feixiang Long, Yiqing Liu, Longlong Fan, Mingqing Liao, Qilong Gao, Hao Lu, Dexiang Gao, Le Kang, Yuzhu Song, Xiuzhu Han, Yue Sun, Naike Shi, Chang Zhou, Jun Chen   +14 more
wiley   +1 more source

The development of a multi-level intervention to improve data quality of the national quality indicators in Swiss long-term care facilities using an Intervention Mapping approach. [PDF]

Front Health Serv
Osińska M, Braun D, Baumann S, Benkert B, Curreri N, Huang J, Simon M, Van Grootven B, Zúñiga F.   +8 more
europepmc   +1 more source

Structurally Complex Precipitates Enhance Strength‐Ductility Synergy in a Duplex Medium Entropy Alloy

Advanced Science, EarlyView.
Strong‐yet‐ductile precipitation‐hardening alloys require novel microstructural complexity of precipitates in particularly at cryogenic condition, to constantly impart strain hardening of hard‐and‐brittle precipitates. The present work creates innovative structurally complex precipitates assembled with dispersed nanocores and a chemical‐heterogeneity ...
Shaohua Gao, Yang Yang, Xiaoxuan Fan, Jinyu Zhang, Shuaiyang Liu, Jiao Li, Hui Wang, Wenli Song, Gang Liu, Jun Sun   +9 more
wiley   +1 more source