Results 61 to 70 of about 48,244 (292)

Hospital nurse staffing models and patient and staff-related outcomes [PDF]

, 2011
BackgroundNurse staffing interventions have been introduced across countries in recent years in response to changing patient requirements, developments in patient care, and shortages of qualified nursing staff.
Schultz, T., Jonathan Drennan, Timothy J Schultz, Halligan, P., O'Mathúna, Dónal, Butler, Michelle, Dónal P O'Mathúna, Halligan, Phil, O\u27Mathúna, Dónal, Sheridan, A., Schultz, Timothy, Collins, R., Michelle Butler, Butler, Michelle M., O'Mathuna, D., Drennan, J., Rita Collins, Phil Halligan, Collins, Rita, Drennan, Jonathan, Butler, M., Ann Sheridan, Eileen Vilis   +22 more
core   +1 more source

Adaptive Staffing Models and their Translation to Future Disaster Response: What Can Be Learned from COVID Unit Staffing?

, 2022
Background: As much as hospital organizations like to be prepared for worst-case scenarios, situations inevitably arise that are unanticipated for which no amount of preparation would ever suffice.
Day, LaKeisha, Day, LaKeisha, PA-C
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Developing an appropriate staff mix for anticoagulation clinics: functional job analysis approach

Journal of Industrial Engineering International, 2018
Anticoagulation clinics (ACCs) are specialty clinics that manage patients with blood clotting problems. Since labor costs usually account for a substantial portion of a healthcare organization’s budget, optimizing the number and types of staff required ...
Desta A. Hailemariam, Xiaojun Shan, Sung H. Chung, Mohammad T. Khasawneh, William Lukesh, Angela Park, Adam Rose   +6 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

An Analysis of Staffing Models for Large U.S. Municipal Cities [PDF]

, 2013
Examines staffing models in an effort to identify industry standards ...
Johnson, Will
core  

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

The association between patient safety outcomes and nurse/healthcare assistant skill mix and staffing levels and factors that may influence staffing requirements

, 2014
IntroductionIdentifying safe approaches to nurse staffing in hospital wards is a key challenge for healthservice providers. The National Institute for Health and Care Excellence (NICE) has beenasked by the Department of Health and NHS England to develop ...
James, Liz, Simon, Michael, Ball, Jane, Jones, Jeremy, Recio, Alejandra, Drennan, Jonathan, Griffiths, Peter   +6 more
core  

Labor Staffing and Scheduling Models for Controlling Service Levels

, 1997
The problems of labor staffing and scheduling have received substantial attention in the literature. We introduce two new models of the labor staffing and scheduling problems that avoid the limitations of existing models.
Thompson, Gary
core   +1 more source