Results 121 to 130 of about 15,512,775 (299)
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
A Developed Methodology in Design of Highly Loaded Tandem Axial Flow Compressor Stage
Journal of Applied Fluid Mechanics, 2016 This study, primarily reports the development of a 3D design procedure for axial flow tandem compressor stages and then the method is used to design a highly loaded tandem stage.
Masoud Boroomand +2 more
doaj
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Validation Analysis During the Design Stage of Text Leveling
Education SciencesUsing leveled books to ascertain students’ reading levels has been found to yield scores that are not sufficiently reliable and that lack criterion-related validation evidence.
Jerome V. D’Agostino, Connie Briggs
doaj +1 more source
Multi-Stage Optimum Design for Composite Pressure Vessels [PDF]
International Journal of Advanced Design and Manufacturing Technology, 2007 In this paper, multi-stage optimum design of composite pressure vessels is presented. The design variables for composite vessels include the head shape, the winding angle, the layer thickness, the number of layers, and the stacking sequence.
Sadegh Rahmati, Ali Khani
doaj
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Parametric Design Program: Enhancing Architects’ Early-Stage Design Decision-making [PDF]
University students including both undergraduates and graduates face numerous challenges in their living environments, particularly in university-provided dormitories or off-campus rental accommodations.
Zhengyang, Ou
core +1 more source
Creative Approaches in Product Design [PDF]
, 2009 Organised by: Cranfield UniversityThis research paper presents a knowledge-based system for creative design tools (CDT). The main aim of the developed CDT system is to provide designers with a flexible creative design environment to enhance their ...
Abdalla, Hassan S., Salah, F.
core +1 more source
, 2009 The first years and the entire first decade after the war confirmed that all areas of theater art had been forcefully occupied by the requirements of social realism. A mere glimpse at the repertoire or a look at the music and stage design used at that time was enough to see that the theater had been absorbed by the spirit of obedience to those Soviet ...
openaire +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source