Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
In the moment: designing for late stage dementia [PDF]
, 2016 This paper presents international multidisciplinary design research to support the wellbeing of people living with dementia. The LAUGH project aims to develop playful artefacts that will contribute to non-pharmacological personalised approaches to caring
Fennell, Jac +7 more
core
Journal of Machine EngineeringThe design of two-stage helical gearboxes inherently involves trade-offs between structural compactness and transmission efficiency. Traditional design methods often fail to capture these competing objectives simultaneously.
Thanh Van Dinh +3 more
doaj +1 more source
Bayesian and frequentist approaches to sequential monitoring for futility in oncology basket trials: A comparison of Simon's two-stage design and Bayesian predictive probability monitoring with information sharing across baskets. [PDF]
PLoS One, 2022 Kaizer A, Zabor E, Nie L, Hobbs B.
europepmc +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Il ruolo del design nella progettazione alberghiera
, 2014 l'autore è stato invitato a stendere un contributo sul ruolo del design nell'ambito della progettazione alberghiera, evidenziando le varie declinazioni della disciplina- design strategico, design dei servizi, design della comunicazione, interior design,
SCULLICA, FRANCESCO +1 more
core
One Stage Power Turbine Preliminary Design and Analysis
Journal of Aerospace Technology and Management, 2015 Design and development of gas turbine components are a complex multidisciplinary process. At the beginning of the power class definition and engine configuration it is necessary to conduct a market study.
Cleverson Bringhenti +3 more
doaj
A Simon's two-stage design trial evaluating the potential role of a kind of honey in preventing chemotherapy-hematopoietic toxicities. [PDF]
J Tradit Complement Med, 2021 Sponghini AP +8 more
europepmc +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
La stilizzazione del costume sul palcoscenico e nel film (traduzione di Tamara Đokić)
eSamizdatItalian translation of Stilizacija kostima na pozornici i na filmu by Milica Babić-Jovanović.
Milica Babić-Jovanović
doaj