Design and analysis of a 2-degree-of-freedom flexure-based micro-motion stage
Advances in Mechanical Engineering, 2016 This article presents the mechanical design, dimensional optimization, finite element analysis, and experimentation of a 2-degree-of-freedom flexure-based micro-motion stage.
Yunsong Du +3 more
doaj +1 more source
Bayesian and frequentist approaches to sequential monitoring for futility in oncology basket trials: A comparison of Simon's two-stage design and Bayesian predictive probability monitoring with information sharing across baskets. [PDF]
PLoS One, 2022 Kaizer A, Zabor E, Nie L, Hobbs B.
europepmc +1 more source
Two-stage designs robust to model uncertainty. [PDF]
D-optimal designs are known to depend quite critically on the particular model that is assumed. These designs tend to concentrate all the experimental runs on a small number of design points and are ideally suited for estimating the coefficients of the ...
Ruggoo, Arvind, Vandebroek, Martina
core
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Impact of ETO propellants on the aerothermodynamic analyses of propulsion components [PDF]
The operating conditions and the propellant transport properties used in Earth-to-Orbit (ETO) applications affect the aerothermodynamic design of ETO turbomachinery in a number of ways. Some aerodynamic and heat transfer implications of the low molecular
Boyle, R. J. +2 more
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In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
One Stage Power Turbine Preliminary Design and Analysis
Journal of Aerospace Technology and Management, 2015 Design and development of gas turbine components are a complex multidisciplinary process. At the beginning of the power class definition and engine configuration it is necessary to conduct a market study.
Cleverson Bringhenti +3 more
doaj
Aerodynamic performance of a 1.20-pressure ratio fan stage designed for low noise [PDF]
The aerodynamic design and the overall blade element performance of a 51 centimeter diameter fan stage is presented. The stage was designed to minimize the noise generated by rotor stator interactions. The design pressure ratio was 1.20 at a flow of 30.6
Lewis, G. W., Jr., Moore, R. D.
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Long term sustainable product development at the packaging sector [PDF]
, 2011 This paper outlines the importance of sustainable product developments and their role in securing a sustainable future through current practices and procedures.
Cheung, Wai Ming +3 more
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FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source