Results 91 to 100 of about 15,512,775 (299)

Design and Testing of a 2-DOF Flexure-based Compliant Stage

MATEC Web of Conferences, 2017
This paper presents the mechanical design and testing of a 2-DOF flexure-based compliant stage. The prismatic joints are first discussed. To obtain high resonance frequency and decoupled property, the stage composed of four parallel chains with ...
Du Yunsong, Li Tiemin, Ji Wei, Jiang Yao
doaj   +1 more source

Adapting Simon's Two-Stage Design for Efficient Screening of Filovirus Vaccines in Non-Human Primates. [PDF]

Vaccines (Basel), 2022
Niemuth NA, Sabourin CL, Ward LA.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

What is sought from graphic designers? A first thematic analysis of job offers for graphic design positions in the United Kingdom

, 2016
An empirically grounded understanding about which knowledge and skills that are sought from designers is missing for a number of professional subfields of design. This gap in research challenges i) design educators in planning their educational offerings
Person, Oscar, Nicoletti Dziobczenski, Paulo, Dziobczenski, Paulo Roberto Nicoletti, Paulo Roberto Nicoletti Dziobczenski, Oscar Person   +4 more
core   +1 more source

A stratified adaptive two-stage design with co-primary endpoints for phase II clinical oncology trials. [PDF]

BMC Med Res Methodol, 2022
Cabarrou B, Leconte E, Sfumato P, Boher JM, Filleron T.   +4 more
europepmc   +1 more source

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

A batch-effect adjusted Simon's two-stage design for cancer vaccine clinical studies. [PDF]

Biometrics, 2021
Wang C, Wang Z, Rosner GL, Huh WK, Roden RBS, Bae S.   +5 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Design and analysis of a 2-degree-of-freedom flexure-based micro-motion stage

Advances in Mechanical Engineering, 2016
This article presents the mechanical design, dimensional optimization, finite element analysis, and experimentation of a 2-degree-of-freedom flexure-based micro-motion stage.
Yunsong Du, Tiemin Li, Yao Jiang, Haitong Wang   +3 more
doaj   +1 more source