Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
12951304Cyber-physical production systems (CPPS) are responsible for a significant portion of manufacturers' carbon emissions. Since 80% of product-related environmental impacts are determined at the design stage, there is a need for CPPS manufacturers ...
Cowen, Adam +3 more
core +1 more source
Optimal two-stage design of single arm Phase II clinical trials based on median event time test. [PDF]
PLoS One, 2021 Park Y.
europepmc +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
DESIGN-STAGE ADJUSTMENT OF ROTOR CRITICAL SPEEDS
Advanced Engineering Research, 2011 Know-how and the computer-applied diversity algorithm (removal) for the operational and critical rotation speeds of the rotor at the design stage (critical frequencies adjustment) are offered.
Oleg O. Polushkin, Oleg A. Polushkin
doaj
Design considerations for Factorial Adaptive Multi-Arm Multi-Stage (FAST) clinical trials
TrialsBackground Multi-Arm, Multi-Stage (MAMS) clinical trial designs allow for multiple therapies to be compared across a spectrum of clinical trial phases. MAMS designs fall under several overarching design groups, including adaptive designs (AD) and multi ...
Jonathan Beall +7 more
doaj +1 more source
Integrating lived experiences of out-of-hours health services for people with palliative and end-of-life care needs with national datasets for people dying in Scotland in 2016: A mixed methods, multi-stage design. [PDF]
Palliat Med, 2022 Mason B +16 more
europepmc +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
DESIGN-STAGE ADJUSTMENT OF ROTOR CRITICAL SPEEDS
Вестник Донского государственного технического университета, 2018 Know-how and the computer-applied diversity algorithm (removal) for the operational and critical rotation speeds of the rotor at the design stage (critical frequencies adjustment) are offered.
Oleg O. Polushkin, Oleg A. Polushkin
doaj
Design of Deep Learning-Based Pressure Injury Stage Classification Device
Jurnal Rekayasa ElektrikaPressure injury or pressure ulcers could occur due to continuous pressure on the bony prominence of the skin and tissue. Geriatric patients, especially those with limited mobility and several comorbidities, are more susceptible to pressure injury.
Wahmisari Priharti +4 more
doaj +1 more source