Results 101 to 110 of about 7,461,141 (296)

Stage III: [PDF]

, 2020
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Phase II trial of vaccination with autologous, irradiated melanoma cells engineered by adenoviral mediated gene transfer to secrete granulocyte-macrophage colony stimulating factor in patients with stage III and IV melanoma

Frontiers in Oncology
BackgroundIn the era of immune checkpoint blockade, the role of cancer vaccines in immune priming has provided additional potential for therapeutic improvements.
Tamara A. Sussman, Mariano Severgnini, Mariano Severgnini, Anita Giobbie-Hurder, Anita Giobbie-Hurder, Philip Friedlander, Scott J. Swanson, Michael Jaklitsch, Thomas Clancy, Laura A. Goguen, David Lautz, Richard Swanson, Heather Daley, Jerome Ritz, Jerome Ritz, Glenn Dranoff, F. Stephen Hodi, F. Stephen Hodi   +17 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Carlos III, febrero 1998 [PDF]

, 1998
Revista mensual de la Universidad Carlos III de MadridContiene: Entrevista con I. Ramonet, Director de Le Monde Diplomatique; Convenio con el Ministerio del Interior; Entrevista con Pedro Castro, Alcalde de Getafe; El presupuesto de la Universidad crece ...
Universidad Carlos III de Madrid
core   +1 more source

LAURA Completes the Osimertinib Treatment Jigsaw Puzzle of EGFR+ NSCLC from Stage IB to IV: Adjuvant Osimertinib Significantly Improves PFS and CNS Progression in Unresectable Stage III EGFR-Mutated NSCLC Compared to Placebo (LAURA, NCT03521154)

Lung Cancer: Targets and Therapy
Faustine X Luo,1,2 Zhaohui Arter,1,2 Sai-Hong Ignatius Ou,1,2 Misako Nagasaka1– 3 1Chao Family Comprehensive Cancer Center, Orange, CA, 92868, USA; 2University of California Irvine School of Medicine, Orange, CA, 92868, USA; 3St.
Luo FX, Arter Z, Ou SI, Nagasaka M
doaj  

Surgical management of both stage III and stage IV pulmonary carcinoid tumors confers survival benefitCentral MessagePerspective

JTCVS Open
Objective: Pulmonary carcinoid tumors are an uncommon entity, with an incidence of 1.35 cases per 100,000 individuals. Although decisions about surgical resection are commonly made similarly to those for non–small cell lung cancer, data surrounding the ...
J. Asher Jenkins, MD, Pedro Augusto Reck Dos Santos, MD, MS, PhD, Zhong Gu, MS, Matthew Buras, MS, Juan M. Farina, MD, Nathan Y. Yu, MD, Yanmei Peng, MD, PhD, Jason Wampfler, BS, Cecilia Benz, MD, Vinicius Ernani, MD, Jonathan D'Cunha, MD, PhD, Stephen D. Cassivi, MD, MS, Ping Yang, MD, PhD   +12 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Boletín III, año 3, n. 17, marzo-abril 1994 [PDF]

, 1994
Revista mensual de la Universidad Carlos III de MadridContiene: Órganos de gobierno: Acuerdos de la Comisión Gestora. — Claustro Constituyente: La convocatoria del Claustro Constituyente; El reglamento de funcionamiento del Claustro provisional ...
Universidad Carlos III de Madrid
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source