Results 111 to 120 of about 7,461,141 (296)

Carlos III, marzo 1998 [PDF]

, 1998
Revista mensual de la Universidad Carlos III de MadridContiene: Mujeres; Una discriminación "sutil"; El maltrato, una epidemia social; Las mujeres en el mundo; Las mujeres en el mundo; Las españolas soportan el paro más elevado de la UE; De misoginias y ...
Universidad Carlos III de Madrid
core   +1 more source

A LODDS-based nomogram for overall and cancer-specific survival in stage III-IV gastric signet ring cell carcinoma

Frontiers in Molecular Biosciences
ObjectiveGastric cancer is a serious human chronic disease. The gastric signet ring cell carcinoma (GSRCC) is the most-dangerous subtype with several acute complications, including gastrointestinal hemorrhage, gastric perforation, pyloric obstruction and
Cenzhu Wang, Ying Fang, Yuhan Zhang, Shuhan Feng, Rui Hou, Hanfang Fan, Zeyu Wang, Lei Liu, Junli Ding, Junying Xu   +9 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Chronopharmacology of verapamil in Stage I-II arterial hypertension

Кардиоваскулярная терапия и профилактика, 2009
Aim. To compare the pharmacokinetics and pharmacodynamics of verapamil retard, regularly taken by patients  with Stage I-II arterial hypertension (AH). Material and methods. The effects of the administration time (morning vs. evening) on verapamil retard
V. G. Belolipetskaya, D. F. Guranda, E. Yu. Fedorova, V. M. Gorbunov, N. A. Belolipetsky, A. V. Zhezlova, O. Yu. Isaykina, E. A. Zhabina, I. E. Koltunov   +8 more
doaj  

Health Services Access Inequalities in Brazil Result in Poorer Outcomes for Stage III NSCLC—RELANCE/LACOG 0118

JTO Clinical and Research Reports
Introduction: Stage III NSCLC is a heterogeneous disease, representing approximately one-third of newly diagnosed lung cancers. Brazil lacks detailed information regarding stage distribution, treatment patterns, survival, and prognostic variables in ...
Vladmir C. Cordeiro de Lima, MD, PhD, Ana Gelatti, MD, MSc, José F.P. Moura, MD, PhD, Aline F. Fares, MD, MSc, Gilberto de Castro, Jr., MD, PhD, Clarissa Mathias, MD, PhD, Ricardo M. Terra, MD, PhD, Gustavo Werutsky, MD, PhD, Marcelo Corassa, MD, Luiz Henrique L. Araújo, MD, PhD, Eduardo Cronenberger, MD, MSc, Fernanda K. Fujiki, MD, Sandro Reichow, MD, Antônio Vinícius T. da Silva, MD, Tércia V. Reis, MD, Mônica Luciana A. Padoan, MD, Patrícia Pacheco, MD, Rosely Yamamura, MD, Caroline Kawamura, MD, Eldsamira Mascarenhas, MD, MSc, Rafaela G. de Jesus, MSc, Gustavo Gössling, MD, Clarissa Baldotto, MD, PhD   +22 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Carlos III, n. 7, marzo 1999 [PDF]

, 1999
Revista mensual de la Universidad Carlos III de MadridContiene: Actualidad: Veinte años de Constitución española; Borrell quiere que los políticos vayan a la Universidad; Los profesores Thomas Kailath y Michael Hitt, nuevos "Honoris Causa"; los alumnos ...
Universidad Carlos III de Madrid
core   +1 more source