Results 101 to 110 of about 1,458,489 (296)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Sequential Choice and R&D Racing [PDF]
This paper develops a framework to analyze how choices are made when R&D competition occurs between two firms, and the aggressiveness-time tradeoffs have to be resolved in multiple stages.
Hans W. Gottinger
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Crossings, 2017 A play is meant for stage performance. Translating a dramatic work is, in many ways, different from translating the other genres of literature, for the language spoken in a play is colloquial and not necessarily formal.
Mohammad Shahadat Hossain
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Transforming timing diagrams into knowledge acquisition in automated specification
, 2007 Requirements engineering is an important part of developing programs. It is an essential stage of the software development process that defines what a product or system should to achieve.
Joochim, Tossaporn, Poppleton, Mike
core
Sviluppo di un sensore interferometrico per il controllo del posizionamento di un rugosimetro ottico [PDF]
, 2001 The optical profilometer that is under development at the Mechanical Engineering Department of the University of Cagliari (DiMeCa) requires a translation stage able to displace part of the optical system with sub-micrometric resolution. This
Baldi A, Bertolino F, Ginesu F, Scanu A
core
TRANSLATION PRACTICE AT THE MODERN STAGE
, 2022 The significance of translation at the modern stage is analyzed. The translation functions are considered. Questions are raised about the need for translation practice in the 21st century. Problems multilingualism and related processes.
openaire +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Translating disability on stage: resistant performances
MonTI. Monografías de Traducción e InterpretaciónTranslation in its many forms, as an interlingual practice, as well as a social and human practice, plays a central role across and beyond geographical and cultural borders, as well as across social categories. Theatre translation, including self-translation, deserves further attention as a powerful form of identity construction and an opportunity for ...
openaire +3 more sources