Results 151 to 160 of about 465,803 (260)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Translation and cross-cultural adaptation of the Rapid Prime Diet Quality Score Screener (rPDQS) for Spanish primary care. [PDF]

Aten Primaria
Bennasar-Veny M, Colom-Rosselló M, Montemayor S, Abbate M, Romaguera D, Yañez AM.   +5 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Navigating international academic collaboration: The Arabic translation and cultural adaptation of the Quality Maternal and Newborn Care Framework index. [PDF]

PLoS One
Zaza K, Symon A, Hassan S, Ali-Masri H, McNeill J, Stockdale J, Alhulaibi W, Mortensen B.   +7 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Multi-omics profiling identifies inosine as a key metabolite associated with embryonic arrest in hydrosalpinx-associated infertility. [PDF]

EBioMedicine
Peng Y, Fang Y, Wang N, Wang X, Liu D, Li M, Liu Y, Yan L, Yuan P, Liang H, Qiao J.   +10 more
europepmc   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

The impact of large language models on collaborative learning processes and outcomes in higher education for English translation. [PDF]

Sci Rep
Quan X.
europepmc   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Bridging the gap between public health, academia and policy. [PDF]

BMJ Glob Health
Christen P, Dawa J, Ahmed O, Akinyi F, Ameyo Masakhwe B, Bekalo DB, Biwot C, Bosire AB, Charles G, Gathoni V, Gaythorpe KAM, Geoffrey G, Gowa S, Hamumy FS, Kagiri H, Kamundia G, Kamunya S, Kariuki P, Khalayi L, Kombe I, Kwamboka P, Liétar P, Likalamu N, Lugonzo B, Mariita V, Masinde A, Mbithi M, McCabe R, Monari FN, Ondicho Motiri F, Muchiri AM, Mudamba A, Mugo PW, Mutono N, Muriithi M, Musasia R, Mutunga M, Mwangi W, Nalwa J, Ngeno KI, Nyaberi JM, Nzoka PM, Ojal J, Okech T, Okunga E, Omondi E, Osoro J, Osoro P, Patel A, Sayianka S, Shigoli T, Silali C, Thendu MM, van Elsland SL, Wanjiku KA, Muchemi P, Whittles LK, Winskill P, Ombajo LA, Thumbi SM, Watson OJ.   +60 more
europepmc   +1 more source