Results 31 to 40 of about 689,585 (301)

Diversification of a protein kinase cascade: IME-2 is involved in nonself recognition and programmed cell death in Neurospora crassa. [PDF]

open access: yes, 2012
Kinase cascades and the modification of proteins by phosphorylation are major mechanisms for cell signaling and communication, and evolution of these signaling pathways can contribute to new developmental or environmental response pathways.
Bueche, Joanna A   +2 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Aesthetic art of stained glass in the middle Ages Study (historical analysis)

open access: yesالاكاديمي, 2017
This paper deals with the role of the clergy in the Church and artists in the emergence of this art, which is represented by an atmosphere of spiritual, aesthetic, artistic, technical and engineering very magnificence and is located in two Find.Chapter ...
Raad mutar majeed
doaj   +1 more source

O “novo papel comunicativo” do vitral na sociedade actual [PDF]

open access: yes, 2010
In medieval times stained glass worked as an illustrated bible to an illiterate society. In the twentieth century, with the development of science and technology glass became even more versatile widely spread and insuperable from our society.
Almeida, Teresa   +2 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Microscopy with ultraviolet surface excitation for rapid slide-free histology. [PDF]

open access: yes, 2017
Histologic examination of tissues is central to the diagnosis and management of neoplasms and many other diseases, and is a foundational technique for preclinical and basic research.
Bishop, John   +10 more
core   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Reetablering av norsk glassmaleri 1900–1913

open access: yesKunst og Kultur
I begynnelsen av 1900-tallet ble produksjonen av monumentale glassmalerier reetablert i Norge. I perioden 1900 til 1913 ble de fire første glassmaleriverkstedene etablert.
Elin Braskerud Tangevold
doaj   +1 more source

Le vitrail médiéval en Europe : dix ans d’une recherche foisonnante

open access: yesPerspective, 2009
The dismantling of stained glass windows during World War II and their reinstallation, once properly documented, following the war, radically changed art historians’ consideration of these works.
Brigitte Kurmann-Schwarz   +1 more
doaj   +1 more source

A Stained Glass Ceiling? Mitt Romney and Mormonism [PDF]

open access: yes, 2017
Did Mitt Romney’s religion—Mormonism—help or hurt him in his campaigns for the presidency? While Romney’s religious affiliation was generally viewed as an electoral liability, Americans’ ambivalence about Mormons presented the possibility that, depending
Campbell, David E
core   +1 more source

Home - About - Disclaimer - Privacy