Results 201 to 210 of about 38,124 (276)

Modulation of the Stress Granule Component Carhsp1 Mitigates Disease‐Associated Deficits in Spinocerebellar Ataxia Type 3 Mouse Models

Movement Disorders, EarlyView.
Abstract Background Spinocerebellar ataxia type 3 (SCA3) is a polyglutamine (polyQ) neurogenerative disorder that results from CAG trinucleotide repeat expansions in the ATXN3 gene, leading to toxic protein aggregate formation and cellular pathway dysfunction.
Tiago Moreira‐Gomes, Adriana Marcelo, Ana Teresa Rajado, Rafael G. Costa, Ricardo Afonso‐Reis, Cristiana R. Madeira, Inês T. Afonso, David V.C. Brito, Adriana A. Vaz, Clévio Nóbrega   +9 more
wiley   +1 more source

Not just a garbage truck: No-go decay plays a role during embryo development in zebrafish. [PDF]

PLoS Biol
Plastrik AR, Zaher HS.
europepmc   +1 more source

Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control

Medicinal Research Reviews, EarlyView.
ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi, Xiya Huang, Chunjun Ye, Yishan Lu, Yanyan Liu, Yuquan Wei, Xiawei Wei   +6 more
wiley   +1 more source

Stall force measurement of the kinesin-3 motor KIF1A using a programmable DNA origami nanospring. [PDF]

Elife
Takamatsu N, Furumoto H, Ariga T, Iwaki M, Hayashi K.   +4 more
europepmc   +1 more source

Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano, Giulia Apprato, Serena Francisco, Giuseppe Ermondi, Giulia Caron   +4 more
wiley   +1 more source

Profiling RNA G-Quadruplexes In vivo. [PDF]

Curr Protoc
Yang B, Ding Y, Zhang Y.
europepmc   +1 more source

Navigating the Rapids: How Non‐Governmental Organization Managers Develop Strategic Adaptation to Repressive Political Environments

Public Administration and Development, EarlyView.
ABSTRACT This article explores the management adaptation strategies non‐governmental organizations (NGOs) managers employ in order to operate in repressive political environments. It answers the question: how do NGO managers initiate, manage and sustain internal change when the political/regulatory environment changes?
Charles Kaye‐Essien, Shahjahan Bhuiyan, Ghadeer Ali   +2 more
wiley   +1 more source

Genomic and translational insights into eIF2B-mediated salt tolerance in sea rice HD961. [PDF]

BMC Biol
Chen H, Chen M, Yang S, Zhou H, Xie Z, Huang Y, Chen D.   +6 more
europepmc   +1 more source

The Politics of Policy Robustness: A Central Paradox and Computational Review of Adaptive Policymaking

Public Administration and Development, EarlyView.
ABSTRACT Policy robustness, that is, the capacity of policies to sustain performance across diverse and uncertain futures, is increasingly considered a core objective of public policymaking. Although adaptive policymaking is widely promoted as an approach to achieving policy robustness, it suffers from a central paradox highlighted by theories of the ...
Ola G. El‐Taliawi, Nihit Goyal
wiley   +1 more source

Transcription-Coupled Nucleotide Excision Repair: A Faster Solution or the Only Option? [PDF]

Biomolecules
Khobta A, Sarmini L.
europepmc   +1 more source