Results 81 to 90 of about 6,707,439 (298)

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Effect of Indigofera sp. Diet Towards Blood Serum Biochemistry of Indonesian Crossbred Native Chickens [PDF]

BIO Web of Conferences
A study was conducted to assess the effects of Indigofera sp. meal on the serum biochemistry of Kampung Unggul Balitbangtan (KUB) chickens, a native strain released by the Indonesian Minister of Agriculture via Decree No. 274/Kpts/SR.120/02/2014.
Dharmawan Rachmad, Parwati Ida Ayu, Suyasa I Nyoman, Utami Anastasia Sischa Jati   +3 more
doaj   +1 more source

Standard Methods of The Division of Laboratories And Research of The New York State Department of Health [PDF]

, 1940

openalex   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Standard Methods for the Examination of Dairy Products [PDF]

, 1949
A. H. Robertson, Luther A. Black, Robert S. Breed, Angel de la Garza Brito, Raoul F. Cowley, James Gibbard   +5 more
openalex   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

958 Simplifying high-parameter phenotypic and functional characterization of cancer immune cells

Journal for ImmunoTherapy of Cancer, 2023
Christina Loh, Deeqa Mahamed, Geneve Awong, Leslie Fung   +3 more
doaj   +1 more source

Screening local Lactobacilli from Iran in terms of production of lactic acid and identification of superior strains

Biological Journal of Microorganism, 2015
Introduction: Lactobacilli are a group of lactic acid bacteria that their final product of fermentation is lactic acid. The objective of this research is selection of local Lactobacilli producing L (+) lactic acid.
Fatemeh Soleimanifard, Maryam Ghobadi Dana, Zahra Piravivanak   +2 more
doaj  

Raising the standards by standardization? [PDF]

Journal of Mathematics Teacher Education, 2021
openaire   +2 more sources