Results 71 to 80 of about 5,851,097 (290)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Estimating the Ratio of Means in a Zero-Inflated Poisson Mixture Model
StatsThe problem of estimating the ratio of the means of a two-component Poisson mixture model is considered, when each component is subject to zero-inflation, i.e., excess zero counts. The resulting zero-inflated Poisson mixture (ZIPM) model can be viewed as
Michael Pearce, Michael D. Perlman
doaj +1 more source
Robust Standard Error Estimators for Panel Models: A Unifying Approach
Journal of Statistical Software, 2017 The different robust estimators for the standard errors of panel models used in applied econometric practice can all be written and computed as combinations of the same simple building blocks.
Giovanni Millo
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
IEEE AccessSliding mode control is a promising approach for designing controllers for systems with empirical characteristics. This is a favored nonlinear control strategy that effectively addresses the uncertainties present in derived mathematical models.
Jim George, Geetha Mani
doaj +1 more source
Responses’ Prediction Standard Error Analysis in Pareto Solutions
MATEC Web of Conferences, 2017 A Pareto front provides to the decision-maker a set of optimal solutions from where a unique solution should be selected to solve a multiresponse problem.
Costa Nuno, Lourenço João
doaj +1 more source
Feature Selection in k-Median Clustering [PDF]
, 2004 An e ective method for selecting features in clustering unlabeled data is proposed based on changing the objective function of the standard k-median clustering algorithm.
Mangasarian, Olvi, Wild, Edward
core +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source