Results 111 to 120 of about 5,314,348 (335)

The Effective Lagrangian in the Randall-Sundrum Model and Electroweak Physics

, 2002
We consider the two-brane Randall-Sundrum (RS) model with bulk gauge fields. We carefully match the bulk theory to a 4D low-energy effective Lagrangian. In addition to the four-fermion operators induced by KK exchange we find that large negative S and T ...
A. Pomarol, A. Pomarol, B. Holdom, B. Holdom, B. Holdom, B. Holdom, C. Csáki, C. Csáki, C. Csáki, C. Csáki, C.P. Burgess, Csaba Csáki, D. Choudhury, D.C. Kennedy, D.C. Kennedy, E. Witten, E. Witten, G.F. Giudice, H. Davoudiasl, H. Davoudiasl, H. Georgi, J. Erler, J. Maldacena, John Terning, Joshua Erlich, K. Cheung, K. Yamawaki, L. Randall, L. Randall, L. Randall, L. Randall, M. Chaichian, M. Golden, M.E. Peskin, M.E. Peskin, M.E. Peskin, N. Arkani-Hamed, N. Arkani-Hamed, O. Aharony, P. Das, R. Rattazzi, S. Chang, S.B. Bae, S.B. Bae, S.J. Huber, S.J. Huber, S.S. Gubser, T. Appelquist, T. Appelquist, T. Appelquist, T. Han, T.G. Rizzo, U. Mahanta, W.D. Goldberger, W.D. Goldberger   +54 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The hierarchion, a relaxion addressing the Standard Model’s hierarchies

Journal of High Energy Physics, 2018
We present a mechanism that addresses the electroweak, the strong CP, and the flavor hierarchies of the Standard Model (including neutrino masses) in a unified way. The naturalness of the electroweak scale is solved together with the strong CP problem by
Oz Davidi, Rick S. Gupta, Gilad Perez, Diego Redigolo, Aviv Shalit   +4 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Constraints on the quartic Higgs self-coupling from double-Higgs production at future hadron colliders

Journal of High Energy Physics, 2019
We study the indirect constraints on the quartic Higgs self-coupling that arise from double-Higgs production at future hadron colliders. To this purpose, we calculate the two-loop contributions to the gg → hh amplitudes that involve a modified h 4 vertex.
Wojciech Bizoń, Ulrich Haisch, Luca Rottoli   +2 more
doaj   +1 more source

On Higgs self-coupling parameter λ of the standard model

Nuclear Physics B, 2015
Thinking about the Higgs field doublet Hi of the standard model as obeying, in addition to the usual properties, a Weyl-type equation on the Goldstone 3-sphere of the UY(1)×SUL(2) gauge symmetry, we study underlying features of the free parameters μ2 and λ of the classical Higgs potential.
openaire   +3 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Leptogenesis in parity solutions to the strong CP problem and Standard Model parameters

Journal of High Energy Physics
We study the simplest theories with exact spacetime parity that solve the strong CP problem and successfully generate the cosmological baryon asymmetry via decays of right-handed neutrinos.
Juanca Carrasco-Martinez, David I. Dunsky, Lawrence J. Hall, Keisuke Harigaya   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

U(1) flavour symmetries as Peccei-Quinn symmetries

Journal of High Energy Physics, 2019
We investigate to what extent a generic, generation-dependent U(1) symmetry acting on the quark Yukawa operators can reduce the number of free parameters by forcing some entries in the Yukawa matrices to vanish.
Fredrik Björkeroth, Luca Di Luzio, Federico Mescia, Enrico Nardi   +3 more
doaj   +1 more source