Results 91 to 100 of about 5,314,348 (335)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Natural quark mixing and inverse seesaw in a left-right model with an axion

Journal of High Energy Physics, 2019
We consider a minimal left-right model with a Peccei-Quinn symmetry, where generalised charge conjugation plays the role of the left-right symmetry. We show how the spontaneous breaking of the Peccei-Quinn symmetry by a scalar singlet can provide us with
Alex G. Dias, Julio Leite
doaj   +1 more source

Conformal Cosmological Model Parameters with Distant SNe Ia Data: "gold" and "silver"

, 2010
Assuming that supernovae type Ia (SNe Ia) are standard candles one could use them to test cosmological theories. The Hubble Space Telescope team analyzed 186 SNe Ia\cite{Riess_04} to test the Standard Cosmological model (SC) associated with expanded ...
ALEXANDER F. ZAKHAROV, Avelino P. P., Barbashov B. M., Barbashov B. M., Caldwell R. R., Lichnerowicz A., Seljak U., VICTOR N. PERVUSHIN, Weyl H., York J. W.   +9 more
core   +1 more source

Determinations of Standard Model Parameters from Lattice QCD

, 1997
In this talk I review some recent results from lattice QCD calculations which aim to a more accurate determination of the Standard Model parameters in the quark sector. After a review of our current knowledge of these parameters, I present lattice results for the strange, charm and bottom quark masses, the CKM matrix element $V_{ub}$ and the complex ...
openaire   +3 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Constraints on the parameters of the neutrino extension of the Standard Model

European Physical Journal C: Particles and Fields
Heavy neutral leptons (HNLs) are hypothetical particles proposed as a potential explanation for neutrino oscillations and the generation of the baryon asymmetry in the Universe.
Volodymyr Gorkavenko, Oleksandr Khasai, Oleg Ruchayskiy, Mariia Tsarenkova   +3 more
doaj   +1 more source

On the first-principles determination of the Standard Model fundamental\n parameters in the quark sector [PDF]

, 2014
B. Blossier
openalex   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

An Improved Standard Model Prediction Of BR(B -> tau nu) And Its Implications For New Physics

, 2009
The recently measured B -> tau nu branching ratio allows to test the Standard Model by probing virtual effects of new heavy particles, such as a charged Higgs boson.
A. Stocchi, Aaltonen, Abdallah, Abulencia, Achard, Adachi, Adachi, Adam, Aglietti, Aglietti, Amsler, Andersen, Artuso, Aubert, Aubert, Aubert, Aubert, Aubert, Aubert, Aubert, Aubert, Aubert, Ball, Barberio, Blanke, Bona, Bona, Bona, Bona, Bona, Buras, Buras, C. Schiavi, C. Tarantino, Cabibbo, Charles, Chivukula, Ciuchini, Ciuchini, Ciuchini, D'Ambrosio, Deschamps, E. Franco, F. Parodi, G. Martinelli, Gabrielli, Gabrielli, Gambino, Gardi, Glashow, Grzadkowski, Grzadkowski, Haber, Hall, Heister, Hokuue, Hou, Iijima, Ikado, Isidori, Itoh, Kamenik, Kobayashi, L. Silvestrini, Lange, Lubicz, M. Bona, M. Ciuchini, M. Pierini, Misiak, Misiak, Satoyama, Tanaka, V. Lubicz, V. Sordini, V. Vagnoni   +75 more
core   +3 more sources