Results 81 to 90 of about 5,314,348 (335)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Sequentially loop suppressed fermion masses from a single discrete symmetry

open access: yesJournal of High Energy Physics, 2020
We propose a systematic and renormalizable sequential loop suppression mechanism to generate the hierarchy of the Standard Model fermion masses from one discrete symmetry.
Carolina Arbeláez   +4 more
doaj   +1 more source

Standard model parameters from a global fit to LEP data

open access: yesPhysics Letters B, 1993
Abstract A set of formulae in the framework of the minimal standard model and a corresponding FORTRAN code, TOPAZO, for the analysis of cross sections and asymmetries around the Z 0 resonance are used to analyze the 1989 and 1990 data collected by the four LEP collaboration.
G. Montagna   +2 more
openaire   +3 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Negative contributions to S in an effective field theory

open access: yes, 1997
We show that an effective field theory that includes non-standard couplings between the electroweak gauge bosons and the top and bottom quarks may yield negative contributions to both the S and T oblique radiative electroweak parameters.
Dobrescu, Bogdan A., Terning, John
core   +3 more sources

Discreteness in parameters of the Standard Model

open access: yesJournal of Physics: Conference Series, 2013
Tuning effect in particle masses manifests itself in integer relations between lepton masses and parameters of the pion (its mass, the mass splitting and fπ). It involves parameters of constituent quark model and basic values of the Standard Model: masses of vector and scalar bosons, QED parameters and the top quark mass.
openaire   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Towards testing interacting cosmology by distant type Ia supernovae

open access: yes, 2005
We investigate the possibility of testing cosmological models with interaction between matter and energy sector. We assume the standard FRW model while the so called energy conservation condition is interpreted locally in terms of energy transfer.
G. Schwarz   +4 more
core   +1 more source

A relation between the Barbero–Immirzi parameter and the standard model [PDF]

open access: yesPhysics Letters B, 2010
It has been shown that Sakharov's induced, from the fields entering the standard model, Barbero-Immirzi parameter assumes, in the framework of euclidean formalism, the UV cutoff-independent value, 1/9. The calculus uses the Schwinger's proper-time formalism, the Seeley-DeWitt heat-kernel expansion, and it is akin to the derivation of the ABJ chiral ...
Broda, Bogusław, Szanecki, Michał
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Home - About - Disclaimer - Privacy