Results 111 to 120 of about 171,523,269 (258)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The impact of land consolidation on farmer income: evidence from high-standard farmland construction in China

Frontiers in Sustainable Food Systems
Land consolidation has become an organized and widely implemented project in rural areas. However, research remains somewhat scarce on the contributing mechanism of land consolidation to farmer income in developing countries.
Xiaoxuan Chen, Zhou Xue, Guoying Han, Qiang Gao   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Does Construction of High-Standard Farmland Improve Total Factor Productivity of Grain? Evidence from China, 2000–2021

Land
This study investigates the impact of China’s construction of high-standard farmland (CHSF) initiatives on grain productivity, focusing on total factor productivity growth of grain (TFPG) from 2000 to 2021.
Mande Zhu, Dongdong Ge, Menghan Wang, Saffa Mohamed Massaquoi, Zhixin Wu   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Endobronchial Valve as Treatment of Emphysema Compared with Standard Medical Care: an Evidence-based Case Report

Acta Medica Indonesiana, 2016
Aim: to determine the effectiveness of endobronchial valve placement as treatment of emphysema compared to medical care. Methods: literature searching regarding comparison of endobronchial valve and medical care as treatment of emphysema on PubMed ...
Eric D Tenda, Abraham Yakub
doaj   +2 more sources

Safeguarding Maritime Traditions: Proving Traditional Fishing Rights Under International Law

Agenda Internacional
One of the most controversial sources of public international law is customary international law, whose identification by international courts remains a significant challenge for both doctrine and jurisprudence.
Milene Vanessa Chagua Zúñiga
doaj  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Are randomized controlled trials as gold standard for high level evidence a pragmatic approach in the era of precision medicine and real-world evidence

Liaquat Medical Research Journal
Randomized controlled trials (RCTs) have been considered as the gold standard for evaluating medical interventions due to their robust methodology, limited introduction of bias, and strength in establishing strong evidence to show better effect of a ...
Binafsha Manzoor Syed
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source