Results 121 to 130 of about 171,523,269 (258)

Therapeutic Advances in Obesity: How Real-World Evidence Impacts Affordability Beyond Standard of Care

Pragmatic and Observational Research
Dimitrios Patoulias,1,2 Theocharis Koufakis,2 Ieva Ruža,3 Mohamed El-Tanani,4 Manfredi Rizzo5 1Outpatient Department of Cardiometabolic Medicine, Second Department of Cardiology, General Hospital “hippokration”, Aristotle University of ...
Patoulias D, Koufakis T, Ruža I, El-Tanani M, Rizzo M   +4 more
doaj  

A comprehensive evidence-based intervention programme significantly reduces intensive care unit-acquired weakness and improves functional recovery: a retrospective analysis

Journal of Rehabilitation Medicine
Background: Intensive care unit-acquired weakness (ICU-AW) affects 25–50% of critically ill patients, resulting in prolonged hospitalization and impaired functional recovery.
Hongrui Zhu, Yueming Zhang, Yan Zhou, Hongxia Yan   +3 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Should RCT's be used as the gold standard for evidence based medicine? [PDF]

Integr Med Res, 2019
Ahuja AS.
europepmc   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Skewed Sociolinguistic Awareness of a Native Non-standard Dialect: Evidence from the Cypriot Greek Writing of Greek Cypriot Students. [PDF]

Front Psychol, 2017
Ayiomamitou I, Yiakoumetti A.
europepmc   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Challenging script concordance test reference standard by evidence: do judgments by emergency medicine consultants agree with likelihood ratios? [PDF]

Int J Emerg Med, 2014
Ahmadi SF, Khoshkish S, Soltani-Arabshahi K, Hafezi-Moghadam P, Zahmatkesh G, Heidari P, Baba-Beigloo D, Baradaran HR, Lotfipour S.   +8 more
europepmc   +1 more source