Results 141 to 150 of about 8,457,878 (300)
ECO, the Evidence & Conclusion Ontology: community standard for evidence information. [PDF]
Nucleic Acids Res, 2019 Giglio M +14 more
europepmc +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Liability Insurance under the Negligence Rule [PDF]
We analyze the efficiency properties of the negligence rule with liability insurance, when the tort-feasor's behavior is imperfectly observable both by the insurer and the court.
Claude Fluet, Marie-Cécile Fagart
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
THEORETICAL BASICS OF SCIENTIFIC EVIDENCE IN CRIMINAL PROCEEDINGS
Zeszyty Naukowe Wyższej Szkoły Finansów i Prawa w Bielsku-Białej, 2016 The paper is a theoretical consideration on the scientific evidence in a criminal proceeding, presented as following: the explanation of the term “scientific evidence”, the review of the existing definitions of scientific evidence (i.e. by methodological,
Anna Ibek, Monika Suchojad
doaj +2 more sources
Skewed Sociolinguistic Awareness of a Native Non-standard Dialect: Evidence from the Cypriot Greek Writing of Greek Cypriot Students. [PDF]
Front Psychol, 2017 Ayiomamitou I, Yiakoumetti A.
europepmc +1 more source
Metric Construction, Stopping Times and Path Coupling
, 2005 In this paper we examine the importance of the choice of metric in path coupling, and the relationship of this to \emph{stopping time analysis}. We give strong evidence that stopping time analysis is no more powerful than standard path coupling.
Bordewich, Magnus +2 more
core +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Challenging script concordance test reference standard by evidence: do judgments by emergency medicine consultants agree with likelihood ratios? [PDF]
Int J Emerg Med, 2014 Ahmadi SF +8 more
europepmc +1 more source