Results 21 to 30 of about 528,012 (215)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Research on the safety threshold of radio wave explosion-proof
Gong-kuang zidonghua, 2023 The powerful radio waves can ignite explosive gases. Therefore, it is necessary to reasonably set the radio wave explosion-proof safety power and energy threshold emitted by the radio transmitter to limit the radio wave power and energy emitted by the ...
SUN Jiping +3 more
doaj +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Taking the Evolution of the Standards of Proof for a Criminal Conviction Seriously
Quaestio FactiThe article offers a diachronic and comparative analysis of different standards of proof for a criminal conviction. The first part focuses on the attempt of medieval and early modern Roman-canon systems to clarify this type of rule through a network of ...
Jacopo Della Torre
doaj +1 more source
Standard of Proof Required to Issue an Arrest Warrant for Genocide
Merkourios, 2011 At the time of writing this case note, the case against Omar Al Bashir is the only genocide case before the InternationalCriminal Court. So far, the main legal question concerns whether the existence of reasonable grounds to believe that a personhas ...
Enrique Carnero Rojo
doaj +3 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
INTERNAL CONVICTION OR THE STANDARD OF PROOF?
Правовое государство: теория и практикаThe article, devoted in general to evidence in criminal proceedings, focuses on the problem of standards of proof and their role in ensuring the fairness of court decisions.
MASHOVETS Asiia Okeanovna
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VOL. 2011, 4(5)Polish Antitrust Experience with Hub-and-Spoke Conspiracies [PDF]
Yearbook of Antitrust and Regulatory Studies, 2011 A hub-and-spoke conspiracy involves an exchange of confidential information primarily concerning future prices. The exchange takes place generally between competing distributors via a common supplier but a reverse relationship is also possible.
Antoni Bolecki
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source