Results 31 to 40 of about 528,012 (215)

Proving Unlawful Discrimination in Capital Cases: In Quest of an Adequate Standard of Proof

Utrecht Journal of International and European Law, 2017
In spite of some early judicial, political and scholarly discussions, as well as more recent scientific explorations of the topic, problems and concerns with proving discrimination in individual capital cases continue to be among the most debatable ...
Gregor Maučec
doaj   +1 more source

The Criminalization of Immigration and Intellectual Disability in the United States

Critical Social Work, 2020
Public attitudes, negative stereotypes, and stigma are essential to cultural narratives about the membership status of people with intellectual disability and people who have immigrated to the United States.
Lauren A. Ricciardelli, Larry Nackerud, Adam E. Quinn   +2 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

“POST-INVESTIGATIVE” FAMILIARISATION WITH CRIMINAL CASE MATERIALS IN THE CONTEXT OF BALANCING PUBLIC AND PRIVATE INTERESTS

Правовое государство: теория и практика
The article, devoted in general to evidence in criminal proceedings, focuses on the problem of standards of proof and their role in ensuring the fairness of court decisions.
ROSSINSKY Sergey Borisovich
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

The Standard of Proof in Criminal Proceedings: the Threshold to Prove Guilt under Ethiopian Law

Mizan Law Review, 2015
The standard of proof plays a vital role in the process of administration of justice. In criminal proceedings, the standard stipulates the degree to which the party who has the burden of proof needs to establish the facts constituting the elements of ...
HA Zemichael
doaj   +1 more source

A New Proof of the Expected Frequency Spectrum under the Standard Neutral Model. [PDF]

PLoS ONE, 2015
The sample frequency spectrum is an informative and frequently employed approach for summarizing DNA variation data. Under the standard neutral model the expectation of the sample frequency spectrum has been derived by at least two distinct approaches ...
Richard R Hudson
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Switching between standard coral reef benthic monitoring protocols is complicated: proof of concept [PDF]

PeerJ, 2019
Monitoring the state of coral reefs is necessary to identify drivers of change and assess effectiveness of management actions. There are several widely-used survey methods, each of which is likely to exhibit different biases that should be quantified if ...
Henri Vallès, Hazel A. Oxenford, Alex Henderson   +2 more
doaj   +2 more sources