Results 41 to 50 of about 168,186,227 (228)

Switching between standard coral reef benthic monitoring protocols is complicated: proof of concept [PDF]

PeerJ, 2019
Monitoring the state of coral reefs is necessary to identify drivers of change and assess effectiveness of management actions. There are several widely-used survey methods, each of which is likely to exhibit different biases that should be quantified if ...
Henri Vallès, Hazel A. Oxenford, Alex Henderson   +2 more
doaj   +2 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Burden and Standard of Proof in Trade Secret Misappropriation Litigation in China: Second-Instance Judgment in the “Bell-Type Furnace Lifting Device” Trade Secret Infringement Case (2022, Supreme People’s Court Civil Final No. 719)

Journal of Intellectual Property
In a trade secret infringement action, the plaintiff, who seeks to claim damages from the defendant, bears the burden of proof. However, in such cases, the majority of the evidence is within the defendant’s control.
Dae Soon Jung
doaj   +1 more source

Implementation and Optimization of Zero-Knowledge Proof Circuit Based on Hash Function SM3

Sensors, 2022
With the increasing demand for privacy protection in the blockchain, the universal zero-knowledge proof protocol has been developed and widely used. Because hash function is an important cryptographic primitive in a blockchain, the zero-knowledge proof ...
Yang Yang, Shangbin Han, Ping Xie, Yan Zhu, Zhenyang Ding, Shengjie Hou, Shicheng Xu, Haibin Zheng   +7 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Proof of Conjectures on the Standard Deviation, Skewness and Kurtosis of the Shifted Gompertz Distribution

Revstat Statistical Journal, 2021
Three conjectures on the standard deviation, skewness and kurtosis of the shifted Gompertz distribution, as the shape parameter increases to +∞, are proved. In this regard, the exponential integral function and polygamma functions are used in the proofs.
Fernando Jiménez Torres
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Impact of the New Approach to Article 102 TFEU on the Enforcement of the Polish Prohibition of Dominant Position Abuse [PDF]

Yearbook of Antitrust and Regulatory Studies, 2010
This paper will analyze the impact of the modernized approach to Article 102 TFEU on the application of the prohibition of dominant position abuse contained in Polish competition law. For that purpose, several questions will be answered. Has the consumer-
Konrad Kohutek
doaj  

Transcript of the Seminar “Increasing Enforcement to Deal with Negative Consequences of Significant Market Power in Digital Ecosystems: Alternatives, Pros and Cons, Counterarguments” October 19, 2023

Современная конкуренция, 2023
The seminar is devoted to alternative legal ways in enhance competition policy enforcement towards large digital platforms and their ecosystems. Effects-based, or rule of reason competition enforcement that requires case-specific economic analysis shows ...
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source