Results 81 to 90 of about 521,158 (314)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Commodity price uncertainty in developing countries [PDF]

Commodity export price uncertainty is typically measured as the standard deviation of the terms of trade, but this approach encounters at least three objections. First, terms of trade indices are unsuitable as proxies for commodity price movements per se.
Jan Dehn
core  

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Analysis and Evaluation of Pulse Rise Time Uncertainty in the Metrology Support for Aviation Equipment

Hangkong gongcheng jinzhan, 2018
The pulse signal is an important basic parameter in metrology support for aviation equipment, and the calibration device of oscilloscope calibrator is an important standard for measuring the rise time of pulse signal.
Li Xiaohui, Li Qiongwei, Dong Zhiming
doaj   +1 more source

XML-based IUPAC standard for experimental, predicted, and critically evaluated thermodynamic property data storage and capture (ThermoML) (IUPAC Recommendations 2006)

, 2006
Committee on Printed and Electronic PublicationsThermoML is an Extensible Markup Language (XML)-based new IUPAC standard for storage and exchange of experimental, predicted, and critically evaluated thermophysical and thermochemical property data.
Goodwin, A.R.H., Frenkel, Michael, Wakeham, William A., Wakeham, W.A., Frenkel, M., Robert D. Chiroco, Chirico, Robert D., Diky, V., Dong, Q., Goodwin, Anthony R.H., Stephen E. Stein, Stein, S.E., Königsberger, E., Königsberger, Erich, Anthony R. H. Goodwin, Erich Königsberger, Marsh, Kenneth N., Diky, Vladimir, Qian Dong, Marsh, K.N., Chiroco, R.D., Dymond, J.H., Dong, Qian, Vladimir Diky, Kenneth N. Marsh, Michael Frenkel, Dymond, John H., William A. Wakeham, Stein, Stephen E., John H. Dymond   +29 more
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Uncertainty Evaluation for Determination of Sibutramine in Health Food by HPLC-MS/MS

Natural Product Communications
High-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was used to determine the content of sibutramine in health foods according to the BJS 201701 standard Determination of Compounds such as Sibutramine in Food.
Zi-Shan Gong, Qiao-yun Guo, Jing Zhang, Shuo Gong, Fang Liu, Liang Xu   +5 more
doaj   +1 more source

Sources of Uncertainty and Influencing Factors in the Analysis of Volatile Components in Blood Using Headspace Gas Chromatography

Fayixue Zazhi
ObjectiveTo use uncertainty as an indicator to evaluate the main factors affecting data quality in the quantitative analysis of 12 volatile components in blood, including ethanol and toluene, and to assess the impact of different quality parameters, such
ZHENG Qiong-ying, FENG Xue-yi, DENG Hong-xiao, YU Jia-xin, DUAN Wen-jia, QIAO Zheng, WANG Xin, LIU Wei, YUN Ke-ming, CHEN Hang, XIANG Ping   +10 more
doaj   +1 more source