Results 221 to 230 of about 17,206,157 (354)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Assessing ChatGPT's Capability as a New Age Standardized Patient: Qualitative Study.

JMIR Med Educ
Cross J, Kayalackakom T, Robinson RE, Vaughans A, Sebastian R, Hood R, Lewis C, Devaraju S, Honnavar P, Naik S, Joseph J, Anand N, Mohammed A, Johnson A, Cohen E, Adeniji T, Nnenna Nnaji A, George JE.   +17 more
europepmc   +1 more source

Functional evaluation of penile hemodynamics [PDF]

, 1988
Bookstein, Brindley, Buvat, Ek, Jevtich, Juenemann, Jünemann, Karacan, Kockott, Lue, Lue, Newman, Porst, Sidi, Stief, van Arsdalen, Virag, Virag, Virag, Virag, Zorgniotti   +20 more
core   +1 more source

Changes in Student Performance and Confidence with a Standardized Patient and Standardized Colleague Interprofessional Activity

American Journal of Pharmaceutical Education, 2015
Marie L. Davies, K. Schonder, S. Meyer, D. Hall   +3 more
semanticscholar   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Bridging Simulation and Practice in Medical History Taking: A Comprehensive Needs Assessment of Standardized Patient Competencies in Early Clinical Exposure. [PDF]

J Adv Med Educ Prof
Baimai S, Vanicharoenchai V, Iramaneerat C.   +2 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Anger De-escalation: A Standardized Patient Workshop for Third- and Fourth-Year Medical Students. [PDF]

MedEdPORTAL
Gouge K, Schadler A, Fletcher KE.
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Effect of high-fidelity human patient simulator manikins combined with standardized patient simulation scenario on clinical thinking in pediatric nursing education. [PDF]

BMC Nurs
Hu LY, Li SQ, Zhou ZY, Wang ML, Zhou LS.
europepmc   +1 more source