Results 41 to 50 of about 4,667,313 (305)

A multi-tiered model of ethical challenges in nursing practice: a qualitative phenomenological study

open access: yesBMC Nursing
Background Nurses face multi-level ethical challenges in complex clinical environments. However, current research lacks a holistic analysis of the interacting factors.
Lina Cao   +3 more
doaj   +1 more source

Enhancing first-attempt success in radial artery cannulation: a PDCA-driven approach for anesthesiology residency training

open access: yesFrontiers in Surgery
ObjectiveThis study aimed to evaluate the effectiveness of the Plan-Do-Check-Act (PDCA) cycle in improving the first-attempt success rate of radial artery cannulation among anesthesiology residents undergoing standardized training.MethodsEighty-six ...
Meng Zhang   +6 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Design and development of a standardized Mitsubishi PLC program troubleshooting and repair training manual for machine maintenance personnel at TTAI [PDF]

open access: yes, 2004
Plan BThis research was conducted to design and develop a standardized Mitsubishi PLC program troubleshooting and repair training manual for TTAI Machine Maintenance (M/M) personnel.
Tada, Mariko
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The learning curve of transanal total mesorectal excision(taTME)and its standardized training

open access: yes结直肠肛门外科, 2022
After more than 10 years of development, transanal total mesorectal excision (taTME) still faces many challenges. The main reason is that taTME technology is relatively complex and has a long learning curve. Most data show that the number of cases in the
Luo Shuangling, Kang Liang
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

Report of online regional training course on onboard fishing handling

open access: yes, 2022
This report is a part of an online regional training course on Onboard Fish Handling organized through the Zoom platform under the situation of the Coronavirus- 2019 (COVID-19) pandemic in the Southeast Asian region and all over the world.

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