Results 181 to 190 of about 1,361,200 (287)

Building an international platform for the research, development, and dissemination of new knowledge in the field of laboratory animal science, technology, and experimental medicine

Animal Models and Experimental Medicine
Muhammad Iqbal Choudhary
doaj   +1 more source

Abnormal Cardiovascular Responses During Orthostatic Hypotension in Cardiac Amyloidosis Revealed by Semi-Sitting/Standing Stress Echocardiography. [PDF]

JACC Case Rep
Iwataki M, Miki H, Onoue T, Nagata Y, Levine RA, Otsuji Y, Kataoka M.   +6 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

From Alert to Action: Electronic Practice Advisory Improves DSMES Referrals Over 18 Months. [PDF]

Diabetes Care
Donahue KE, Halladay JR, Chen P, Mottus K, Goeke-Austin K, Rees J, Vu MB, Thomas A, Hammond K, Merritt A, Young LA.   +10 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The Significance of Lower Limb Asymmetry in the Assessment of Spinal Deformities in Individuals with Scoliotic Posture and Scoliosis. [PDF]

J Clin Med
Puchalska-Sarna A, Walicka-Cupryś K, Trzeciak J, Lenart-Domka E, Baran R, Guz P, Kinasz-Jakubiec A, Baran J.   +7 more
europepmc   +1 more source

Stand Planı / Stand Area

Turkish Journal of Biochemistry, 2015
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Cerebral Oxygenation Changes During Sequential Postural Transitions From Supine to Walking in Healthy Adults: An Exploratory Near-Infrared Spectroscopy Study. [PDF]

Cureus
Oike K, Tsubaki A, Takahashi T.
europepmc   +1 more source