Results 31 to 40 of about 12,724 (295)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Deux millénaires ou deux siècles de constructions mégalithiques au Sénégal et en Gambie ? Nouvelles dates pour Wanar et révision des contextes archéologiques

Afrique Archéologie Arts, 2022
The megaliths of Senegal and The Gambia comprise nearly 30,000 erected stones recorded over a surface of around 30,000 km², mainly in the northern basin of the Gambia River.
Luc Laporte, Jean-Claude Lefèvre, Matar Ndiaye, Christine Oberlin, Adrien Delvoye, Mathilde Stern, Abdoul Kader Faye, Aziz Ballouche, Jean-Paul Cros, Selim Djouad, Laurent Quesnel   +10 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

83. Standing Stones and Stone Circles in Yorkshire [PDF]

Man, 1914
n ...
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Cultures lithiques dans les monts Mandara au Cameroun

Afrique Archéologie Arts, 2009
Research work carried out recently in the Mandara mountains in northern Cameroon enable us to appreciate the dynamism of its cultural stone heritage through the standing stones, rock art, mobile art and various stone structures.
Narcisse Santores Tchandeu
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Distribution des pratiques mégalithiques actuelles et subactuelles et dynamique du peuplement dans le Faro au nord du Cameroun durant ces deux derniers siècles

Afriques
In the Faro Region, Northern Cameroon, megalithism appears on recent remains of modern villages and continues still today. But this heritage is still largely underexploited and threatened by destruction. The goal our study is first of all aims to analyze
Alice Lucie Mezop Temgoua-Noumissing
doaj   +1 more source

Measuring distinction in the megalithic architecture of the Carnac region: from sign to material

Journal of Neolithic Archaeology, 2010
Barely two centuries after the appearance of the first archaeologically- visible elements that served to define the earliest Neolithic in the west of France around 4900 BC – that is, domestic buildings, pottery, a distinctive flint technology, and other
Serge Cassen, Pierre Pétrequin, Christine Boujot, Salvador Domínguez-Bella, Mikaël Guiavarc’h, Guirec Querré   +5 more
doaj   +1 more source