Results 31 to 40 of about 875,677 (285)

Primary Squamous Cell Carcinoma of Renal Pelvis Associated with Staghorn Calculi Masquerading as Xanthogranulomatous Pyelonephritis [PDF]

National Journal of Laboratory Medicine, 2018
Primary squamous cell carcinoma of renal pelvis is a rare tumour associated with long standing renal calculi. We report here a case in which patient presented with pain abdomen and renal calculus with left pelvi ureteric junction obstruction and ...
Shilpa Manigatta Doddagowda, Kalyani Raju, Sreeramalu PN, Gudibande Narasappa Manjunath   +3 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Le mégalithisme au Grassland (Cameroun occidental)

Afrique Archéologie Arts, 2009
Megalithism, which appeared in prehistoric times and has been extinct for years in various regions, is still practised in Cameroon. All over the world and in many domains, it presents on the one hand disturbing similarities, and on the other differences ...
Jean-Paul Notué
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Squamous Cell Carcinoma of the Renal Pelvis as a Result of Long-Standing Staghorn Calculi

Case Reports in Oncology, 2015
We report on a 79-year-old woman with staghorn calculi who presented with severe hypercalcemia. She was later found to have humoral hypercalcemia of malignancy caused by a rare tumor, squamous cell carcinoma of the renal pelvis.
Kamonchanok Jongyotha, Chutintorn Sriphrapradang   +1 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Where do standing stones in the North York Moors National Park tend to be placed? Using ArcGIS Pro to reveal patterns in location placement through analysis of terrain, viewshed, and intervisibility. [PDF]

North York Moors National Park in England is not only beautiful and rugged, but also has a wealth of archaeological material, such as prehistoric standing stones; ‘Menhirs’ stand alone, ‘Standing Stones’ are two or more in close proximity, and ...
Barter, Gracen
core   +3 more sources

Distribution des pratiques mégalithiques actuelles et subactuelles et dynamique du peuplement dans le Faro au nord du Cameroun durant ces deux derniers siècles

Afriques
In the Faro Region, Northern Cameroon, megalithism appears on recent remains of modern villages and continues still today. But this heritage is still largely underexploited and threatened by destruction. The goal our study is first of all aims to analyze
Alice Lucie Mezop Temgoua-Noumissing
doaj   +1 more source

LAPAROSCOPIC MANAGEMENT OF DISTAL URETERIC STONE IN BILHARZIAL URETER: RESULTS OF A SINGLE CENTER PROSPECTIVE STUDY [PDF]

Journal of the Egyptian Society of Parasitology, 2015
No doubt, Bilharzial ureters are complicated by distal stricture due to precipitation of Bilharzial ova in distal ureter. These cases are associated with poorly functioning and grossly hydronephroic kidneys that hinder endoscopic manipulation of the ...
ESSAM RIAD, AHMAD ELBAZ, MAMDOUH ROSHDY, Mohamed Ali, AHMAD KAMAL, AMR ELKHOLY, SAMIR ELGOBASHY, HANI NOUR   +7 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source