Results 51 to 60 of about 29,530 (206)

Phage Therapy for Orthopaedic Infections: The First Three Cases from the United Kingdom

Antibiotics
Background: Bacteriophages (phages) are viruses that infect and kill bacteria. The antimicrobial resistance crisis has driven renewed interest in phage therapy, including the use of phages to treat chronic orthopaedic infections.
Daniela I. Munteanu, John Dunn, Gábor Apjok, Bálint Kintses, Johann Griselain, Griet Steurs, Christel Cochez, Sarah Djebara, Maya Merabishvili, Jean-Paul Pirnay, Vida Štilec, Matjaž Peterka, Emily A. Simpson, Samantha Downie, Alasdair MacInnes, Graeme Nicol, Benedict Clift, Joshua D. Jones   +17 more
doaj   +1 more source

S. aureus colonization and clinical symptoms remain stable upon topical XZ.700 treatment: Results of a double‐blind randomized clinical trial in patients with mild to moderate atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Aim Recovering dysbiosis may improve atopic dermatitis (AD) symptoms. XZ.700 is a recombinant chimeric endolysin that specifically targets Staphylococcus aureus and could be a new treatment option for patients with AD. The aim of this first‐in‐human study was to evaluate the safety, tolerability and efficacy of topical XZ.700 and explore the ...
Laura W. J. van der Meulen, Menthe E. Bergmans, Salma Assil, Naomi Klarenbeek, Marieke L. de Kam, Alexa J. Tibboel, Thorsten Brach, Bjorn L. Herpers, Johan Frieling, Vincent de Jong, Benthe Freyee, Martijn B. A. van Doorn, Robert Rissmann, Tessa Niemeyer–van der Kolk   +13 more
wiley   +1 more source

Activity and Characteristics of a New Staphylococcus Phage 94

Experimental Biology and Medicine, 1973
SummaryStaphylococcus phage 94, formerly designated WH-1, was found to type 119 (13.2%) of 900 clinical isolates which were untypable with the basic series of typing phages. Strains typed by this phage were uniformly resistant to penicillin, ampicillin, and colymycin. A lytic spectrum for phage 94 is presented and the phage is shown to be antigenically
L E, Blouse, W B, Stringfield, R V, Marraro, H J, Dupuy   +3 more
openaire   +2 more sources

Biological properties of Staphylococcus virus ΦSA012 for phage therapy

Scientific Reports, 2022
AbstractStaphylococcus virus ΦSA012 has a wide host range and efficient lytic activity. Here, we assessed the biological stability of ΦSA012 against temperature, freeze-thawing, and pH to clinically apply the phage. In addition, inoculation of ΦSA012 through i.p. and i.v.
Jumpei Fujiki, Tomohiro Nakamura, Keisuke Nakamura, Keita Nishida, Yurika Amano, Yusaku Watanabe, Satoshi Gondaira, Masaru Usui, Masaru Shimizu, Kazuhiko Miyanaga, Shinya Watanabe, Tomohito Iwasaki, Kotaro Kiga, Tomoko Hanawa, Hidetoshi Higuchi, Teiji Sawa, Yasunori Tanji, Yutaka Tamura, Longzhu Cui, Hidetomo Iwano   +19 more
openaire   +3 more sources

Living Microbial Drugs

Chemistry – A European Journal, EarlyView.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source

The Use of Adaptive Phage in the Typing of Staphylococcus

Nippon Saikingaku Zasshi, 1962
Even by the use of enough high titar of bacteriophage, the phage typing of staphylococcus for the examination of staphylococcus infection or food poisoning encounters several times the difficulty of typing due to inhibition or host range spreading etc.This difficulty induced us to try the use of adaptive phage in the examination of staphylococcus ...
openaire   +3 more sources

Antibacterial Hydrogel Dressing With Ca2+‐Dependent Hyaluronidase Responsiveness for Accelerating Wound Healing via On‐Demand Release of AIE Photosensitizers

Exploration, EarlyView.
This study innovates a Ca2+‐responsive hydrogel dressing that releases AIE photosensitizers on‐demand. Low Ca2+ enhances bacterial hyaluronidase (HAase) activity, degrading hyaluronic acid dressing to trigger antibacterial ROS release, while high Ca2+ inhibits HAase, preventing overdosing.
Rongwei Cui, Hao Yang, Miaomiao Kang, Zhijun Zhang, Weilin Xu, Yang Jiang, Lizhou Xu, Xiao‐Yong Zhan, Luhan Zhang, Yunsheng Xu, Dong Wang, Ben Zhong Tang, Danyang Li   +12 more
wiley   +1 more source

Isolation and Characterization of New Bacteriophages against Staphylococcal Clinical Isolates from Diabetic Foot Ulcers

Viruses, 2023
Staphylococcus sp. is the most common bacterial genus in infections related to diabetic foot ulcers (DFUs). The emergence of multidrug-resistant bacteria places a serious burden on public health systems.
Lucile Plumet, Madjid Morsli, Nour Ahmad-Mansour, Fernando Clavijo-Coppens, Laurence Berry, Albert Sotto, Jean-Philippe Lavigne, Denis Costechareyre, Virginie Molle   +8 more
doaj   +1 more source

On‐site pilot‐scale advanced oxidation pretreatment of hospital wastewater: assessment of pharmaceuticals, pathogens, antibiotic resistance genes and acute ecotoxicity

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Hospital premises generate wastewater containing a wide spectrum of contaminants, such as pharmaceutically active compounds (PhACs), antibiotic resistance genes (ARGs) and pathogenic microorganisms, whilst plenty of them are classified under the antibiotic resistant bacteria (ΑRΒ) category.
Andreas Kaliakatsos, Iosifina Gounaki, Spyros Dokianakis, Georgios Gkotsis, Maria‐Christina Nika, Eleni Aleiferi, Athanasios S Stasinakis, Nikos Katsarakis, Nikolaos S Thomaidis, Thrassyvoulos Manios, Michalis S Fountoulakis, Danae Venieri   +11 more
wiley   +1 more source

CHARACTERISTIC OF SENSITIVITY TO ANTIBIOTICS AND PHAGES OF STAPHYLOCOCCI STRAINS, ISOLATED FROM MICE REPRODUCTIVE TRACT

Patologìâ, 2014
Aim. To study the characteristic of sensitivity to antibiotics and phages of staphylococci strains, isolated from mice reproductive tract. Methods and results. Isolated from the mice vagina staphylococci strains were identified as species S. aureus, S.
T. N. Shevchenko, O. S. Voronkova, A. I. Vinnikov   +2 more
doaj   +1 more source