Results 111 to 120 of about 45,046 (289)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The Influence of General Relativity on the Spins of Celestial Bodies in Inclined Orbits

The Astrophysical Journal
Through the Rossiter–McLaughlin effect, several hot Jupiters have been found to exhibit spin–orbit misalignment and even retrograde orbits. The high obliquity observed in these planets can be attributed to two primary formation mechanisms, as summarized ...
Huan-Rong Yuan, Ying Wang, Xin Wu, Ji-Wei Xie, Hui-Gen Liu, Ji-Lin Zhou, Wei Sun   +6 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

CZ Aqr: An Oscillating Eclipsing Algol-type System Composed of a δ Sct Primary Star and a Subgiant Star in a Quadruple System

The Astrophysical Journal
Eclipsing Algol-type systems containing a δ Scuti (hereafter δ Sct) star enable precise determination of physical parameters and the investigation of stellar internal structure and evolution.
Qi-Huan Zeng, Wen-Ping Liao, Sheng-Bang Qian, Lin-Jia Li, Ping Li, Zhao-Long Deng   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Protective Effect of the Persian Gulf brittle star Ophiocoma Erinaceus extract on carbon tetrachloride (CCl4) induced liver damage in adult male Wistar rats

مجله دانشگاه علوم پزشکی بیرجند, 2015
Background and Aim:  Brittle star possess  bioactive compounds which confer the wound healing capacity and regenerative potency of damaged  arms and organisms to this creature.
Aida Soheili, Javad Baharara, Naser Mahdavi Shahri, Saeede Zafar Balanejad, Elaheh Amini   +4 more
doaj  

Stars Born in the Wind. II. Widespread Extra-planar Star Formation in M82’s Halo

The Astrophysical Journal
Galaxies evolve in tandem with their environments—mergers and gas inflows drive galaxy growth while galactic outflows launched by supernovae may seed the galactic environment with gas, metals, and energy, fueling star formation far from the main bodies ...
Vaishnav V. Rao, Eric F. Bell, Adam Smercina, Elliott Besirli, Andrew Dolphin, Antonela Monachesi, Benjamin Williams, Julianne J. Dalcanton, Roelof S. de Jong   +8 more
doaj   +1 more source

Fractal star bodies [PDF]

Banach Center Publications, 2009
Irmina Herburt, Maria Moszyńska, Dorette Pronk   +2 more
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source