Results 31 to 40 of about 4,162,760 (300)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
, 1987 Part 1 of the catalog presents an astronomical overview of the Guide Star Catalog, together with its history, the properties of its current implementation, and the prospects for enhancement.
Lasker, Barry M. +2 more
core
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Search for Wide Double Stars in the Guide Star Catalog I. All Sky Properties of the Catalog [PDF]
International Astronomical Union Colloquium, 1992 AbstractThe immediate object of this effort is the first systematic investigation of the guide star catalog as a new source list for the discovery of possible new visual binary stars. In this first paper of the series we detail on the way used to establish the properties of the catalog, i.e.
P.L. Bernacca +7 more
openaire +1 more source
Catalog of X-Ray Detected Be Stars (XDBS)
Research Notes of the AAS, 2022 Abstract We present a catalog of X-ray Detected Be Stars (XDBS) with 161 Be stars from the Be Star Spectra (BeSS) database having X-ray counterparts in the Chandra Source Catalog v2.0, XMM-Newton 4XMM-DR11 Catalog, or Swift 2SXPS Catalog.
Caden Gobat +4 more
openaire +2 more sources
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Prototype Development of the Star Sensor for the KITSAT-3 [PDF]
Journal of Astronomy and Space Sciences, 1995 This report presents the development procedure and the results of a prototype star sensor which can be sued as one of the attitude sensors of the KITSAT-3.
Hyunwoo Lee +3 more
doaj
Catalog of Integrated-light Star Cluster Light Curves in TESS
The Astronomical Journal, 2023 We present the first integrated-light, TESS-based light curves for star clusters in the Milky Way, Small Magellanic Cloud, and Large Magellanic Cloud. We explore the information encoded in these light curves, with particular emphasis on variability.
Tobin M. Wainer +12 more
doaj +1 more source