Results 91 to 100 of about 91,664 (267)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Mass Distribution of Binary Black Hole Mergers from Young and Old Dense Star Clusters

The Astrophysical Journal
Dense star clusters are thought to contribute significantly to the merger rates of stellar-mass binary black holes (BBHs) detected by the LIGO–Virgo–KAGRA collaboration.
Claire S. Ye, Maya Fishbach, Kyle Kremer, Marta Reina-Campos   +3 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Open Star Clusters and Their Asymmetrical Tidal Tails

The Astrophysical Journal
Stars that evaporate from their star cluster by the energy equipartition process end up in either a leading or a trailing tidal tail. In Newtonian gravitation and for open star clusters in the solar vicinity, the tidal threshold, or práh, for escape is ...
Pavel Kroupa, Jan Pflamm-Altenburg, Sergij Mazurenko, Wenjie Wu, Ingo Thies, Vikrant Jadhav, Tereza Jerabkova   +6 more
doaj   +1 more source

Core radius evolution of star clusters [PDF]

, 2003
M. I. Wilkinson, J. R. Hurley, A. D. Mackey, G. F. Gilmore, C. A. Tout   +4 more
openalex   +1 more source

Mass and Rate of Hierarchical Black Hole Mergers in Young, Globular and Nuclear Star Clusters

, 2021
Michela Mapelli, Filippo Santoliquido, Yann Bouffanais, Manuel Arca Sedda, Maria Celeste Artale, Alessandro Ballone   +5 more
openalex   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Young star clusters immersed in intermediate-age fields in the Large Magellanic Cloud bar [PDF]

, 2003
Andrés E. Piatti, D. Geisler, E. Bica, Joan Clària   +3 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The Stellar Initial Mass Function of Early Dark Matter–free Gas Objects

The Astrophysical Journal Letters
Among the remarkable strides made by JWST is the discovery of the earliest star clusters found to date. These have been proposed as early progenitors of globular clusters, which are known to come from the early stages of star formation in the Universe ...
William Lake, Michael Y. Grudić, Smadar Naoz, Naoki Yoshida, Claire E. Williams, Blakesley Burkhart, Federico Marinacci, Mark Vogelsberger, Avi Chen   +8 more
doaj   +1 more source