Results 101 to 110 of about 440,600 (338)

Star-Forming Galaxies at z~2 and the Formation of the Metal-Rich Globular Cluster Population

, 2010
We examine whether the super star-forming clumps (R~1-3 kpc; M~10^8-10^9.5 Msun) now known to be a key component of star-forming galaxies at z~2 could be the formation sites of the locally observed old globular cluster population.
Armandroff, Ashman, Barmby, Bournaud, Bournaud, Bridges, Brodie, Conroy, Cowie, Cresci, Côté, Côté, Daddi, De Angeli, de Grijs, Dekel, Elmegreen, Elmegreen, Elmegreen, Elmegreen, Elmegreen, Elmegreen, Elson, English, Erb, Erb, Escala, Fall, Forbes, Förster Schreiber, Förster Schreiber, Genel, Genzel, Genzel, Halliday, Harris, Huchra, Immeli, Jordán, Kristen L. Shapiro, Kuntschner, Mannucci, McLaughlin, McLaughlin, McLaughlin, Mendel, Minniti, Murray, Natascha M. Förster Schreiber, Noguchi, Peng, Peng, Peng, Pettini, Puzia, Quider, Reddy, Reinhard Genzel, Rhode, Rhode, Rudnick, Scannapieco, Schroder, Searle, Strader, Tacconi, Thomas, Trujillo, van den Bergh, Wilson, Zepf, Zinn   +71 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Internal dynamics of the galaxy cluster Abell 545

, 2011
Diffuse radio emission in galaxy clusters, and their connection with cluster mergers, are still debated. We seek to explore the internal dynamics of the radio halo cluster Abell 545.
Abell, Anders, Ashman, Bacchi, Bardelli, Barrena, Barrena, Barrena, Beers, Beers, Beers, Beers, Beers, Bekki, Bell, Bertin, Binggelli, Bird, Biviano, Bonafede, Boschin, Boschin, Boschin, Boschin, Brunetti, Bullock, Buote, Buote, Böhringer, Carlberg, Cassano, Cassano, Cassano, Cassano, Cassano, Cavaliere, Chilingarian, Chilingarian, D. Eckert, Danese, David, den Hartog, Dolag, Dolag, Donnert, Dressler, Dubinsky, Ellingson, Ensslin, Ensslin, Ensslin, Fadda, Fasano, Ferrari, Ferrari, Ferrari, Finoguenov, Fukugita, Giovannini, Giovannini, Girardi, Girardi, Girardi, Girardi, Girardi, Girardi, Goto, Govoni, Hashimoto, Henriksen, Henry, Hoeft, Kalberla, Kennicutt, Kneib, Landolt, Leccardi, Leccardi, Limber, Lin, Liu, Loeb, M. Girardi, M. Rossetti, Malumuth, Markevitch, Markevitch, Mastropietro, Menci, Merritt, Million, Mushotzky, Navarro, Niederste-Ostholt, Nieto, Okabe, Owers, Pinkney, Pisani, Pisani, Quintana, R. Barrena, Ramella, Ramella, Ricker, Rines, Roettiger, Roettiger, Roettiger, Rossetti, Rudick, S. De Grandi, Salinas, Salinas, Sarazin, Sastry, Schlegel, Schneider, Springel, Struble, Struble, The, Tonry, Tribble, van Dokkum, W. Boschin, Wainer, West, White   +128 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Evolution of Star Clusters within Galaxies Using Self-consistent Hybrid Hydro/N-body Simulations

The Astrophysical Journal
We introduce a GPU-accelerated hybrid hydro/ N -body code ( Enzo-N ) designed to address the challenges of concurrently simulating star clusters and their parent galaxies.
Yongseok Jo, Seoyoung Kim, Ji-hoon Kim, Greg L. Bryan   +3 more
doaj   +1 more source

Modes of clustered star formation

, 2012
The realization that most stars form in clusters, raises the question of whether star/planet formation are influenced by the cluster environment. The stellar density in the most prevalent clusters is the key factor here.
Kaczmarek, T., Olczak, C., Pfalzner, S.
core   +1 more source

Unveiling hidden stellar aggregates in the Milky Way: 1656 new star clusters found in Gaia EDR3 [PDF]

, 2022
Zhihong He, Xiaochen Liu, Yangping Luo, Kun Wang, Qingquan Jiang   +4 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source